REST corepressor 1 (Protein CoREST)
1_MPAMV 6_ EKGPE 11_ VSGKR 16_ RGRNN 21_ AAASA 26_ SAAAA 31_ SAAAS 36_ AACAS 41_ PAATA 46_ ASGAA 51_ ASSAS 56_ AAAAS 61_ AAAAP 66_ NNGQN 71_ KSLAA 76_ AAPNG 81_ NSSSN 86_ SWEEG 91_ SSGSS 96_ SDEEH 101_ GGGGM 106_ RVGPQ 111_ YQAVV 116_ PDFDP 121_ AKLAR 126_ RSQER 131_ DNLGM 136_ LVWSP 141_ NQNLS 146_ EAKLD 151_ EYIAI 156_ AKEKH 161_ GYNME 166_ QALGM 171_ LFWHK 176_ HNIEK 181_ SLADL 186_ PNFTP 191_ FPDEW 196_ TVEDK 201_ VLFEQ 206_ AFSFH 211_ GKTFH 216_ RIQQM 221_ LPDKS 226_ IASLV 231_ KFYYS 236_ WKKTR 241_ TKTSV 246_ MDRHA 251_ RKQKR 256_ EREES 261_ EDELE 266_ EANGN 271_ NPIDI 276_ EVDQN 281_ KESKK 286_ EVPPT 291_ ETVPQ 296_ VKKEK 301_ HSTQA 306_ KNRAK 311_ RKPPK 316_ GMFLS 321_ QEDVE 326_ AVSAN 331_ ATAAT 336_ TVLRQ 341_ LDMEL 346_ VSVKR 351_ QIQNI 356_ KQTNS 361_ ALKEK 366_ LDGGI 371_ EPYRL 376_ PEVIQ 381_ KCNAR 386_ WTTEE 391_ QLLAV 396_ QAIRK 401_ YGRDF 406_ QAISD 411_ VIGNK 416_ SVVQV 421_ KNFFV 426_ NYRRR 431_ FNIDE 436_ VLQEW 441_ EAEHG 446_ KEETN 451_ GPSNQ 456_ KPVKS 461_ PDNSI 466_ KMPEE 471_ EDEAP 476_VLDVR
1: Essential component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it serves as a molecular beacon for the recruitment of molecular machinery, including MeCP2 and SUV39H1, that imposes silencing across a chromosomal interval. Plays a central role in demethylation of Lys-4 of histone H3 by promoting demethylase activity of KDM1A on core histones and nucleosomal substrates. It also protects KDM1A from the proteasome. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development and controls hematopoietic differentiation