CASP8-associated protein 2 (FLICE-associated huge protein)
1_MAADD 6_ DNGDG 11_ TSLFD 16_ VFSAS 21_ PLKNN 26_ DEGSL 31_ DIYAG 36_ LDSAV 41_ SDSAS 46_ KSCVP 51_ SRNCL 56_ DLYEE 61_ ILTEE 66_ GTAKE 71_ ATYND 76_ LQVEY 81_ GKCQL 86_ QMKEL 91_ MKKFK 96_ EIQTQ 101_ NFSLI 106_ NENQS 111_ LKKNI 116_ SALIK 121_ TARVE 126_ INRKD 131_ EEISN 136_ LHQRL 141_ SEFPH 146_ FRNNH 151_ KTART 156_ FDTVK 161_ TKDLK 166_ SRSPH 171_ LDDCS 176_ KTDHR 181_ AKSDV 186_ SKDVH 191_ HSTSL 196_ PNLEK 201_ EGKPH 206_ SDKRS 211_ TSHLP 216_ TSVEK 221_ HCTNG 226_ VWSRS 231_ HYQVG 236_ EGSSN 241_ EDSRR 246_ GRKDI 251_ RHSQF 256_ NRGTE 261_ RVRKD 266_ LSTGC 271_ GDGEP 276_ RILEA 281_ SQRLQ 286_ GHPEK 291_ YGKGE 296_ PKTES 301_ KSSKF 306_ KSNSD 311_ SDYKG 316_ ERINS 321_ SWEKE 326_ TPGER 331_ SHSRV 336_ DSQSD 341_ KKLER 346_ QSERS 351_ QNINR 356_ KEVKS 361_ QDKEE 366_ RKVDQ 371_ KPKSV 376_ VKDQD 381_ HWRRS 386_ ERASL 391_ PHSKN 396_ EITFS 401_ HNSSK 406_ YHLEE 411_ RRGWE 416_ DCKRD 421_ KSVNS 426_ HSFQD 431_ GRCPS 436_ SLSNS 441_ RTHKN 446_ IDSKE 451_ VDAMH 456_ QWENT 461_ PLKAE 466_ RHRTE 471_ DKRKR 476_ EQESK 481_ EENRH 486_ IRNEK 491_ RVPTE 496_ HLQKT 501_ NKETK 506_ KTTTD 511_ LKKQN 516_ EPKTD 521_ KGEVL 526_ DNGVS 531_ EGADN 536_ KELAM 541_ KAESG 546_ PNETK 551_ NKDLK 556_ LSFMK 561_ KLNLT 566_ LSPAK 571_ KQPVS 576_ QDNQH 581_ KITDI 586_ PKSSG 591_ VCDSE 596_ SSMQV 601_ KTVAY 606_ VPSIS 611_ EHILG 616_ EAAVS 621_ EHTMG 626_ ETKST 631_ LLEPK 636_ VALLA 641_ VTEPR 646_ IGISE 651_ TNKED 656_ ENSLL 661_ VRSVD 666_ NTMHC 671_ EEPIC 676_ GTETS 681_ FPSPM 686_ EIQQT 691_ ESLFP 696_ STGMK 701_ QTINN 706_ GRAAA 711_ PVVMD 716_ VLQTD 721_ VSQNF 726_ GLELD 731_ TKRND 736_ NSDYC 741_ GISEG 746_ MEMKV 751_ ALSTT 756_ VSETT 761_ ESILQ 766_ PSIEE 771_ ADILP 776_ IMLSE 781_ DNNPK 786_ FEPSV 791_ IVTPL 796_ VESKS 801_ CHLEP 806_ CLPKE 811_ TLDSS 816_ LQQTE 821_ LMDHR 826_ MATGE 831_ TNSVY 836_ HDDDN 841_ SVLSI 846_ DLNHL 851_ RPIPE 856_ AISPL 861_ NSPVR 866_ PVAKV 871_ LRNES 876_ PPQVP 881_ VYNNS 886_ HKDVF 891_ LPNSA 896_ HSTSK 901_ SQSDL 906_ NKENQ 911_ KPIYK 916_ SDKCT 921_ EADTC 926_ KNSPL 931_ DELEE 936_ GEIRS 941_ DSETS 946_ KPQES 951_ FEKNS 956_ KRRVS 961_ ADVRK 966_ SKTIP 971_ RRGKS 976_ TVCLD 981_ KDSRK 986_ THVRI 991_ HQTNN 996_ KWNKR 1001_ PDKSS 1006_ RSSKT 1011_ EKKDK 1016_ VMSTS 1021_ SLEKI 1026_ VPIIA 1031_ VPSSE 1036_ QEIMH 1041_ MLRMI 1046_ RKHVR 1051_ KNYMK 1056_ FKAKF 1061_ SLIQF 1066_ HRIIE 1071_ SAILS 1076_ FTSLI 1081_ KHLNL 1086_ HKISK 1091_ SVTTL 1096_ QKNLC 1101_ DIIES 1106_ KLKQV 1111_ KKNGI 1116_ VDRLF 1121_ EQQLP 1126_ DMKKK 1131_ LWKFV 1136_ DDQLD 1141_ YLFAK 1146_ LKKIL 1151_ VCDSK 1156_ SFGRD 1161_ SDEGK 1166_ LEKTS 1171_ KQNAQ 1176_ YSNSQ 1181_ KRSVD 1186_ NSNRE 1191_ LLKEK 1196_ LSKSE 1201_ DPVHY 1206_ KSLVG 1211_ CKKSE 1216_ ENYQD 1221_ QNNSS 1226_ INTVK 1231_ HDIKK 1236_ NFNIC 1241_ FDNIK 1246_ NSQSE 1251_ ERSLE 1256_ VHCPS 1261_ TPKSE 1266_ KNEGS 1271_ SIEDA 1276_ QTSQH 1281_ ATLKP 1286_ ERSFE 1291_ ILTEQ 1296_ QASSL 1301_ TFNLV 1306_ SDAQM 1311_ GEIFK 1316_ SLLQG 1321_ SDLLD 1326_ SSVNC 1331_ TEKSE 1336_ WELKT 1341_ PEKQL 1346_ LETLK 1351_ CESIP 1356_ ACTTE 1361_ ELVSG 1366_ VASPC 1371_ PKMIS 1376_ DDNWS 1381_ LLSSE 1386_ KGPSL 1391_ SSGLS 1396_ LPVHP 1401_ DVLDE 1406_ SCMFE 1411_ VSTNL 1416_ PLSKD 1421_ NVCSV 1426_ EKSKP 1431_ CVSSI 1436_ LLEDL 1441_ AVSLT 1446_ VPSPL 1451_ KSDGH 1456_ LSFLK 1461_ PDMSS 1466_ SSTPE 1471_ EVISA 1476_ HFSED 1481_ ALLEE 1486_ EDASE 1491_ QDIHL 1496_ ALESD 1501_ NSSSK 1506_ SSCSS 1511_ SWTSR 1516_ SVAPG 1521_ FQYHP 1526_ NLPMH 1531_ AVIME 1536_ KSNDH 1541_ FIVKI 1546_ RRATP 1551_ STSSG 1556_ LKQSM 1561_ MPDEL 1566_ LTSLP 1571_ RHGKE 1576_ ADEGP 1581_ EKEYI 1586_ SCQNT 1591_ VFKSV 1596_ EELEN 1601_ SNKNV 1606_ DGSKS 1611_ THEEQ 1616_ SSMIQ 1621_ TQVPD 1626_ IYEFL 1631_ KDASD 1636_ KMGHS 1641_ DEVAD 1646_ ECFKL 1651_ HQVWE 1656_ TKVPE 1661_ SIEEL 1666_ PSMEE 1671_ ISHSV 1676_ GEHLP 1681_ NTYVD 1686_ LTKDP 1691_ VTETK 1696_ NLGEF 1701_ IEVTV 1706_ LHIDQ 1711_ LGCSG 1716_ GNLNQ 1721_ SAQIL 1726_ DNSLQ 1731_ ADTVG 1736_ AFIDL 1741_ TQDAS 1746_ SEAKS 1751_ EGNHP 1756_ ALAVE 1761_ DLGCG 1766_ VIQVD 1771_ EDNCK 1776_ EEKAQ 1781_ VANRP 1786_ LKCIV 1791_ EETYI 1796_ DLTTE 1801_ SPSSC 1806_ EVKKD 1811_ ELKSE 1816_ PGSNC 1821_ DNSEL 1826_ PGTLH 1831_ NSHKK 1836_ RRNIS 1841_ DLNHP 1846_ HKKQR 1851_ KETDL 1856_ TNKEK 1861_ TKKPT 1866_ QDSCE 1871_ NTEAH 1876_ QKKAS 1881_ KKKAP 1886_ PVTKD 1891_ PSSLK 1896_ ATPGI 1901_ KDSSA 1906_ ALATS 1911_ TSLSA 1916_ KNVIK 1921_ KKGEI 1926_ IILWT 1931_ RNDDR 1936_ EILLE 1941_ CQKRG 1946_ PSFKT 1951_ FAYLA 1956_ AKLDK 1961_ NPNQV 1966_ SERFQ 1971_ QLMKL 1976_FEKSK
1: Participates in TNF-alpha-induced blockade of glucocorticoid receptor (GR) transactivation at the nuclear receptor coactivator level, upstream and independently of NF-kappa-B. Suppresses both NCOA2- and NCOA3-induced enhancement of GR transactivation. Involved in TNF-alpha-induced activation of NF-kappa-B via a TRAF2-dependent pathway. Acts as a downstream mediator for CASP8-induced activation of NF-kappa-B. Required for the activation of CASP8 in FAS-mediated apoptosis. Required for histone gene transcription and progression through S phase