Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase (EC 3.2.1.113) (ER alpha-1,2-mannosidase) (ER mannosidase 1) (ERMan1) (Man9GlcNAc2-specific-processing alpha-mannosidase) (Mannosidase alpha class 1B member 1)
1_MAACE 6_ GRRSG 11_ ALGSS 16_ QSDFL 21_ TPPVG 26_ GAPWA 31_ VATTV 36_ VMYPP 41_ PPPPP 46_ HRDFI 51_ SVTLS 56_ FGENY 61_ DNSKS 66_ WRRRS 71_ CWRKW 76_ KQLSR 81_ LQRNM 86_ ILFLL 91_ AFLLF 96_ CGLLF 101_ YINLA 106_ DHWKA 111_ LAFRL 116_ EEEQK 121_ MRPEI 126_ AGLKP 131_ ANPPV 136_ LPAPQ 141_ KADTD 146_ PENLP 151_ EISSQ 156_ KTQRH 161_ IQRGP 166_ PHLQI 171_ RPPSQ 176_ DLKDG 181_ TQEEA 186_ TKRQE 191_ APVDP 196_ RPEGD 201_ PQRTV 206_ ISWRG 211_ AVIEP 216_ EQGTE 221_ LPSRR 226_ AEVPT 231_ KPPLP 236_ PARTQ 241_ GTPVH 246_ LNYRQ 251_ KGVID 256_ VFLHA 261_ WKGYR 266_ KFAWG 271_ HDELK 276_ PVSRS 281_ FSEWF 286_ GLGLT 291_ LIDAL 296_ DTMWI 301_ LGLRK 306_ EFEEA 311_ RKWVS 316_ KKLHF 321_ EKDVD 326_ VNLFE 331_ STIRI 336_ LGGLL 341_ SAYHL 346_ SGDSL 351_ FLRKA 356_ EDFGN 361_ RLMPA 366_ FRTPS 371_ KIPYS 376_ DVNIG 381_ TGVAH 386_ PPRWT 391_ SDSTV 396_ AEVTS 401_ IQLEF 406_ RELSR 411_ LTGDK 416_ KFQEA 421_ VEKVT 426_ QHIHG 431_ LSGKK 436_ DGLVP 441_ MFINT 446_ HSGLF 451_ THLGV 456_ FTLGA 461_ RADSY 466_ YEYLL 471_ KQWIQ 476_ GGKQE 481_ TQLLE 486_ DYVEA 491_ IEGVR 496_ THLLR 501_ HSEPS 506_ KLTFV 511_ GELAH 516_ GRFSA 521_ KMDHL 526_ VCFLP 531_ GTLAL 536_ GVYHG 541_ LPASH 546_ MELAQ 551_ ELMET 556_ CYQMN 561_ RQMET 566_ GLSPE 571_ IVHFN 576_ LYPQP 581_ GRRDV 586_ EVKPA 591_ DRHNL 596_ LRPET 601_ VESLF 606_ YLYRV 611_ TGDRK 616_ YQDWG 621_ WEILQ 626_ SFSRF 631_ TRVPS 636_ GGYSS 641_ INNVQ 646_ DPQKP 651_ EPRDK 656_ MESFF 661_ LGETL 666_ KYLFL 671_ LFSDD 676_ PNLLS 681_ LDAYV 686_ FNTEA 691_HPLPI
1: Involved in glycoprotein quality control targeting of misfolded glycoproteins for degradation. It primarily trims a single alpha-1,2-linked mannose residue from Man(9)GlcNAc(2) to produce Man(8)GlcNAc(2), but at high enzyme concentrations, as found in the ER quality control compartment (ERQC), it further trims the carbohydrates to Man(5-6)GlcNAc(2)