Putative F-box/LRR-repeat protein 21 (F-box and leucine-rich repeat protein 21) (F-box and leucine-rich repeat protein 3B) (F-box/LRR-repeat protein 3B)
1_MKRNS 6_ LSVEN 11_ KIVQL 16_ SGAAK 21_ QPKVG 26_ FYSSL 31_ NQTHT 36_ HTVLL 41_ DWGSL 46_ PHHVV 51_ LQIFQ 56_ YLPLL 61_ DRACA 66_ SSVCR 71_ RWNEV 76_ FHISD 81_ LWRKF 86_ EFELN 91_ QSATS 96_ SFKST 101_ HPDLI 106_ QQIIK 111_ KHFAH 116_ LQYVS 121_ FKVDS 126_ SAESA 131_ EAACD 136_ ILSQL 141_ VNCSI 146_ QTLGL 151_ ISTAK 156_ PSFMN 161_ VSESH 166_ FVSAL 171_ TVVFI 176_ NSKSL 181_ SSIKI 186_ EDTPV 191_ DDPSL 196_ KILVA 201_ NNSDT 206_ LRLPK 211_ MSSCP 216_ HVSSD 221_ GILCV 226_ ADRCQ 231_ GLREL 236_ ALNYY 241_ ILTDE 246_ LFLAL 251_ SSETH 256_ VNLEH 261_ LRIDV 266_ VSENP 271_ GQIKF 276_ HAVKK 281_ HSWDA 286_ LIKHS 291_ PRVNV 296_ VMHFF 301_ LYEEE 306_ FETFF 311_ KEETP 316_ VTHLY 321_ FGRSV 326_ SKVVL 331_ GRVGL 336_ NCPRL 341_ IELVV 346_ CANDL 351_ QPLDN 356_ ELICI 361_ AEHCT 366_ NLTAL 371_ GLSKC 376_ EVSCS 381_ AFIRF 386_ VRLCE 391_ RRLTQ 396_ LSVME 401_ EVLIP 406_ DEDYS 411_ LDEIH 416_ TEVSK 421_ YLGRV 426_WFPDV
1: Substrate-recognition component of the SCF(FBXL21) E3 ubiquitin ligase complex involved in circadian rhythm function. Plays a key role in the maintenance of both the speed and the robustness of the circadian clock oscillation. The SCF(FBXL21) complex mainly acts in the cytosol and mediates ubiquitination of CRY proteins (CRY1 and CRY2), leading to CRY proteins stabilization. The SCF(FBXL21) complex counteracts the activity of the SCF(FBXL3) complex and protects CRY proteins from degradation. Involved in the hypothalamic suprachiasmatic nucleus (SCN) clock regulating temporal organization of the daily activities (By similarity)