F-box/LRR-repeat protein 3 (F-box and leucine-rich repeat protein 3A) (F-box/LRR-repeat protein 3A)
1_MKRGG 6_ RDSDR 11_ NSSEE 16_ GTAEK 21_ SKKLR 26_ TTNEH 31_ SQTCD 36_ WGNLL 41_ QDIIL 46_ QVFKY 51_ LPLLD 56_ RAHAS 61_ QVCRN 66_ WNQVF 71_ HMPDL 76_ WRCFE 81_ FELNQ 86_ PATSY 91_ LKATH 96_ PELIK 101_ QIIKR 106_ HSNHL 111_ QYVSF 116_ KVDSS 121_ KESAE 126_ AACDI 131_ LSQLV 136_ NCSLK 141_ TLGLI 146_ STARP 151_ SFMDL 156_ PKSHF 161_ ISALT 166_ VVFVN 171_ SKSLS 176_ SLKID 181_ DTPVD 186_ DPSLK 191_ VLVAN 196_ NSDTL 201_ KLLKM 206_ SSCPH 211_ VSPAG 216_ ILCVA 221_ DQCHG 226_ LRELA 231_ LNYHL 236_ LSDEL 241_ LLALS 246_ SEKHV 251_ RLEHL 256_ RIDVV 261_ SENPG 266_ QTHFH 271_ TIQKS 276_ SWDAF 281_ IRHSP 286_ KVNLV 291_ MYFFL 296_ YEEEF 301_ DPFFR 306_ YEIPA 311_ THLYF 316_ GRSVS 321_ KDVLG 326_ RVGMT 331_ CPRLV 336_ ELVVC 341_ ANGLR 346_ PLDEE 351_ LIRIA 356_ ERCKN 361_ LSAIG 366_ LGECE 371_ VSCSA 376_ FVEFV 381_ KMCGG 386_ RLSQL 391_ SIMEE 396_ VLIPD 401_ QKYSL 406_ EQIHW 411_ EVSKH 416_ LGRVW 421_FPDMM
1: Substrate-recognition component of the SCF(FBXL3) E3 ubiquitin ligase complex involved in circadian rhythm function. Plays a key role in the maintenance of both the speed and the robustness of the circadian clock oscillation (PubMed:17463251, PubMed:23452855, PubMed:27565346). The SCF(FBXL3) complex mainly acts in the nucleus and mediates ubiquitination and subsequent degradation of CRY1 and CRY2 (PubMed:17463251, PubMed:23452855, PubMed:27565346). Activity of the SCF(FBXL3) complex is counteracted by the SCF(FBXL21) complex (PubMed:23452855)