Histone deacetylase 9 (HD9) (EC 3.5.1.98) (Histone deacetylase 7B) (HD7) (HD7b) (Histone deacetylase-related protein) (MEF2-interacting transcription repressor MITR)
1_MHSMI 6_ SSVDV 11_ KSEVP 16_ VGLEP 21_ ISPLD 26_ LRTDL 31_ RMMMP 36_ VVDPV 41_ VREKQ 46_ LQQEL 51_ LLIQQ 56_ QQQIQ 61_ KQLLI 66_ AEFQK 71_ QHENL 76_ TRQHQ 81_ AQLQE 86_ HIKEL 91_ LAIKQ 96_ QQELL 101_ EKEQK 106_ LEQQR 111_ QEQEV 116_ ERHRR 121_ EQQLP 126_ PLRGK 131_ DRGRE 136_ RAVAS 141_ TEVKQ 146_ KLQEF 151_ LLSKS 156_ ATKDT 161_ PTNGK 166_ NHSVS 171_ RHPKL 176_ WYTAA 181_ HHTSL 186_ DQSSP 191_ PLSGT 196_ SPSYK 201_ YTLPG 206_ AQDAK 211_ DDFPL 216_ RKTAS 221_ EPNLK 226_ VRSRL 231_ KQKVA 236_ ERRSS 241_ PLLRR 246_ KDGNV 251_ VTSFK 256_ KRMFE 261_ VTESS 266_ VSSSS 271_ PGSGP 276_ SSPNN 281_ GPTGS 286_ VTENE 291_ TSVLP 296_ PTPHA 301_ EQMVS 306_ QQRIL 311_ IHEDS 316_ MNLLS 321_ LYTSP 326_ SLPNI 331_ TLGLP 336_ AVPSQ 341_ LNASN 346_ SLKEK 351_ QKCET 356_ QTLRQ 361_ GVPLP 366_ GQYGG 371_ SIPAS 376_ SSHPH 381_ VTLEG 386_ KPPNS 391_ SHQAL 396_ LQHLL 401_ LKEQM 406_ RQQKL 411_ LVAGG 416_ VPLHP 421_ QSPLA 426_ TKERI 431_ SPGIR 436_ GTHKL 441_ PRHRP 446_ LNRTQ 451_ SAPLP 456_ QSTLA 461_ QLVIQ 466_ QQHQQ 471_ FLEKQ 476_ KQYQQ 481_ QIHMN 486_ KLLSK 491_ SIEQL 496_ KQPGS 501_ HLEEA 506_ EEELQ 511_ GDQAM 516_ QEDRA 521_ PSSGN 526_ STRSD 531_ SSACV 536_ DDTLG 541_ QVGAV 546_ KVKEE 551_ PVDSD 556_ EDAQI 561_ QEMES 566_ GEQAA 571_ FMQQP 576_ FLEPT 581_ HTRAL 586_ SVRQA 591_ PLAAV 596_ GMDGL 601_ EKHRL 606_ VSRTH 611_ SSPAA 616_ SVLPH 621_ PAMDR 626_ PLQPG 631_ SATGI 636_ AYDPL 641_ MLKHQ 646_ CVCGN 651_ STTHP 656_ EHAGR 661_ IQSIW 666_ SRLQE 671_ TGLLN 676_ KCERI 681_ QGRKA 686_ SLEEI 691_ QLVHS 696_ EHHSL 701_ LYGTN 706_ PLDGQ 711_ KLDPR 716_ ILLGD 721_ DSQKF 726_ FSSLP 731_ CGGLG 736_ VDSDT 741_ IWNEL 746_ HSSGA 751_ ARMAV 756_ GCVIE 761_ LASKV 766_ ASGEL 771_ KNGFA 776_ VVRPP 781_ GHHAE 786_ ESTAM 791_ GFCFF 796_ NSVAI 801_ TAKYL 806_ RDQLN 811_ ISKIL 816_ IVDLD 821_ VHHGN 826_ GTQQA 831_ FYADP 836_ SILYI 841_ SLHRY 846_ DEGNF 851_ FPGSG 856_ APNEV 861_ GTGLG 866_ EGYNI 871_ NIAWT 876_ GGLDP 881_ PMGDV 886_ EYLEA 891_ FRTIV 896_ KPVAK 901_ EFDPD 906_ MVLVS 911_ AGFDA 916_ LEGHT 921_ PPLGG 926_ YKVTA 931_ KCFGH 936_ LTKQL 941_ MTLAD 946_ GRVVL 951_ ALEGG 956_ HDLTA 961_ ICDAS 966_ EACVN 971_ ALLGN 976_ ELEPL 981_ AEDIL 986_ HQSPN 991_ MNAVI 996_ SLQKI 1001_ IEIQS 1006_MSLKF
1: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Represses MEF2-dependent transcription
2: Isoform 3 lacks active site residues and therefore is catalytically inactive. Represses MEF2-dependent transcription by recruiting HDAC1 and/or HDAC3. Seems to inhibit skeletal myogenesis and to be involved in heart development. Protects neurons from apoptosis, both by inhibiting JUN phosphorylation by MAPK10 and by repressing JUN transcription via HDAC1 recruitment to JUN promoter