Apoptotic chromatin condensation inducer in the nucleus (Acinus)
1_MWRRK 6_ HPRTS 11_ GGTRG 16_ VLSGN 21_ RGVEY 26_ GSGRG 31_ HLGTF 36_ EGRWR 41_ KLPKM 46_ PEAVG 51_ TDPST 56_ SRKMA 61_ ELEEV 66_ TLDGK 71_ PLQAL 76_ RVTDL 81_ KAALE 86_ QRGLA 91_ KSGQK 96_ SALVK 101_ RLKGA 106_ LMLEN 111_ LQKHS 116_ TPHAA 121_ FQPNS 126_ QIGEE 131_ MSQNS 136_ FIKQY 141_ LEKQQ 146_ ELLRQ 151_ RLERE 156_ AREAA 161_ ELEEA 166_ SAESE 171_ DEMIH 176_ PEGVA 181_ SLLPP 186_ DFQSS 191_ LERPE 196_ LELSR 201_ HSPRK 206_ SSSIS 211_ EEKGD 216_ SDDEK 221_ PRKGE 226_ RRSSR 231_ VRQAR 236_ AAKLS 241_ EGSQP 246_ AEEEE 251_ DQETP 256_ SRNLR 261_ VRADR 266_ NLKTE 271_ EEEEE 276_ EEEEE 281_ EDDEE 286_ EEGDD 291_ EGQKS 296_ REAPI 301_ LKEFK 306_ EEGEE 311_ IPRVK 316_ PEEMM 321_ DERPK 326_ TRSQE 331_ QEVLE 336_ RGGRF 341_ TRSQE 346_ EARKS 351_ HLARQ 356_ QQEKE 361_ MKTTS 366_ PLEEE 371_ EREIK 376_ SSQGL 381_ KEKSK 386_ SPSPP 391_ RLTED 396_ RKKAS 401_ LVALP 406_ EQTAS 411_ EEETP 416_ PPLLT 421_ KEASS 426_ PPPHP 431_ QLHSE 436_ EEIEP 441_ MEGPA 446_ PAVLI 451_ QLSPP 456_ NTDAD 461_ TRELL 466_ VSQHT 471_ VQLVG 476_ GLSPL 481_ SSPSD 486_ TKAES 491_ PAEKV 496_ PEESV 501_ LPLVQ 506_ KSTLA 511_ DYSAQ 516_ KDLEP 521_ ESDRS 526_ AQPLP 531_ LKIEE 536_ LALAK 541_ GITEE 546_ CLKQP 551_ SLEQK 556_ EGRRA 561_ SHTLL 566_ PSHRL 571_ KQSAD 576_ SSSSR 581_ SSSSS 586_ SSSSR 591_ SRSRS 596_ PDSSG 601_ SRSHS 606_ PLRSK 611_ QRDVA 616_ QARTH 621_ ANPRG 626_ RPKMG 631_ SRSTS 636_ ESRSR 641_ SRSRS 646_ RSASS 651_ NSRKS 656_ LSPGV 661_ SRDSS 666_ TSYTE 671_ TKDPS 676_ SGQEV 681_ ATPPV 686_ PQLQV 691_ CEPKE 696_ RTSTS 701_ SSSVQ 706_ ARRLS 711_ QPESA 716_ EKHVT 721_ QRLQP 726_ ERGSP 731_ KKCEA 736_ EEAEP 741_ PAATQ 746_ PQTSE 751_ TQTSH 756_ LPESE 761_ RIHHT 766_ VEEKE 771_ EVTMD 776_ TSENR 781_ PENDV 786_ PEPPM 791_ PIADQ 796_ VSNDD 801_ RPEGS 806_ VEDEE 811_ KKESS 816_ LPKSF 821_ KRKIS 826_ VVSAT 831_ KGVPA 836_ GNSDT 841_ EGGQP 846_ GRKRR 851_ WGAST 856_ ATTQK 861_ KPSIS 866_ ITTES 871_ LKSLI 876_ PDIKP 881_ LAGQE 886_ AVVDL 891_ HADDS 896_ RISED 901_ ETERN 906_ GDDGT 911_ HDKGL 916_ KICRT 921_ VTQVV 926_ PAEGQ 931_ ENGQR 936_ EEEEE 941_ EKEPE 946_ AEPPV 951_ PPQVS 956_ VEVAL 961_ PPPAE 966_ HEVKK 971_ VTLGD 976_ TLTRR 981_ SISQQ 986_ KSGVS 991_ ITIDD 996_ PVRTA 1001_ QVPSP 1006_ PRGKI 1011_ SNIVH 1016_ ISNLV 1021_ RPFTL 1026_ GQLKE 1031_ LLGRT 1036_ GTLVE 1041_ EAFWI 1046_ DKIKS 1051_ HCFVT 1056_ YSTVE 1061_ EAVAT 1066_ RTALH 1071_ GVKWP 1076_ QSNPK 1081_ FLCAD 1086_ YAEQD 1091_ ELDYH 1096_ RGLLV 1101_ DRPSE 1106_ TKTEE 1111_ QGIPR 1116_ PLHPP 1121_ PPPPV 1126_ QPPQH 1131_ PRAEQ 1136_ REQER 1141_ AVREQ 1146_ WAERE 1151_ REMER 1156_ RERTR 1161_ SEREW 1166_ DRDKV 1171_ REGPR 1176_ SRSRS 1181_ RDRRR 1186_ KERAK 1191_ SKEKK 1196_ SEKKE 1201_ KAQEE 1206_ PPAKL 1211_ LDDLF 1216_ RKTKA 1221_ APCIY 1226_ WLPLT 1231_ DSQIV 1236_ QKEAE 1241_ RAERA 1246_ KEREK 1251_ RRKEQ 1256_ EEEEQ 1261_ KEREK 1266_ EAERE 1271_ RNRQL 1276_ EREKR 1281_ REHSR 1286_ ERDRE 1291_ RERER 1296_ ERDRG 1301_ DRDRD 1306_ RERDR 1311_ ERGRE 1316_ RDRRD 1321_ TKRHS 1326_ RSRSR 1331_ STPVR 1336_DRGGR
1: Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets; ACIN1 confers RNA-binding to the complex. The ASAP complex can inhibit RNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function. Induces apoptotic chromatin condensation after activation by CASP3. Regulates cyclin A1, but not cyclin A2, expression in leukemia cells