Guanine nucleotide exchange factor VAV3 (VAV-3)
1_MEPWK 6_ QCAQW 11_ LIHCK 16_ VLPTN 21_ HRVTW 26_ DSAQV 31_ FDLAQ 36_ TLRDG 41_ VLLCQ 46_ LLNNL 51_ RAHSI 56_ NLKEI 61_ NLRPQ 66_ MSQFL 71_ CLKNI 76_ RTFLT 81_ ACCET 86_ FGMRK 91_ SELFE 96_ AFDLF 101_ DVRDF 106_ GKVIE 111_ TLSRL 116_ SRTPI 121_ ALATG 126_ IRPFP 131_ TEESI 136_ NDEDI 141_ YKGLP 146_ DLIDE 151_ TLVED 156_ EEDLY 161_ DCVYG 166_ EDEGG 171_ EVYED 176_ LMKAE 181_ EAHQP 186_ KCPEN 191_ DIRSC 196_ CLAEI 201_ KQTEE 206_ KYTET 211_ LESIE 216_ KYFMA 221_ PLKRF 226_ LTAAE 231_ FDSVF 236_ INIPE 241_ LVKLH 246_ RNLMQ 251_ EIHDS 256_ IVNKN 261_ DQNLY 266_ QVFIN 271_ YKERL 276_ VIYGQ 281_ YCSGV 286_ ESAIS 291_ SLDYI 296_ SKTKE 301_ DVKLK 306_ LEECS 311_ KRANN 316_ GKFTL 321_ RDLLV 326_ VPMQR 331_ VLKYH 336_ LLLQE 341_ LVKHT 346_ TDPTE 351_ KANLK 356_ LALDA 361_ MKDLA 366_ QYVNE 371_ VKRDN 376_ ETLRE 381_ IKQFQ 386_ LSIEN 391_ LNQPV 396_ LLFGR 401_ PQGDG 406_ EIRIT 411_ TLDKH 416_ TKQER 421_ HIFLF 426_ DLAVI 431_ VCKRK 436_ GDNYE 441_ MKEII 446_ DLQQY 451_ KIANN 456_ PTTDK 461_ ENKKW 466_ SYGFY 471_ LIHTQ 476_ GQNGL 481_ EFYCK 486_ TKDLK 491_ KKWLE 496_ QFEMA 501_ LSNIR 506_ PDYAD 511_ SNFHD 516_ FKMHT 521_ FTRVT 526_ SCKVC 531_ QMLLR 536_ GTFYQ 541_ GYLCF 546_ KCGAR 551_ AHKEC 556_ LGRVD 561_ NCGRV 566_ NSGEQ 571_ GTLKL 576_ PEKRT 581_ NGLRR 586_ TPKQV 591_ DPGLP 596_ KMQVI 601_ RNYSG 606_ TPPPA 611_ LHEGP 616_ PLQLQ 621_ AGDTV 626_ ELLKG 631_ DAHSL 636_ FWQGR 641_ NLASG 646_ EVGFF 651_ PSDAV 656_ KPCPC 661_ VPKPV 666_ DYSCQ 671_ PWYAG 676_ AMERL 681_ QAETE 686_ LINRV 691_ NSTYL 696_ VRHRT 701_ KESGE 706_ YAISI 711_ KYNNE 716_ AKHIK 721_ ILTRD 726_ GFFHI 731_ AENRK 736_ FKSLM 741_ ELVEY 746_ YKHHS 751_ LKEGF 756_ RTLDT 761_ TLQFP 766_ YKEPE 771_ HSAGQ 776_ RGNRA 781_ GNSLL 786_ SPKVL 791_ GIAIA 796_ RYDFC 801_ ARDMR 806_ ELSLL 811_ KGDVV 816_ KIYTK 821_ MSANG 826_ WWRGE 831_ VNGRV 836_ GWFPS 841_TYVEE
1: Exchange factor for GTP-binding proteins RhoA, RhoG and, to a lesser extent, Rac1. Binds physically to the nucleotide-free states of those GTPases. Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly (By similarity). May be important for integrin-mediated signaling, at least in some cell types. In osteoclasts, along with SYK tyrosine kinase, required for signaling through integrin alpha-v/beta-1 (ITAGV-ITGB1), a crucial event for osteoclast proper cytoskeleton organization and function. This signaling pathway involves RAC1, but not RHO, activation. Necessary for proper wound healing. In the course of wound healing, required for the phagocytotic cup formation preceding macrophage phagocytosis of apoptotic neutrophils. Responsible for integrin beta-2 (ITGB2)-mediated macrophage adhesion and, to a lesser extent, contributes to beta-3 (ITGB3)-mediated adhesion. Does not affect integrin beta-1 (ITGB1)-mediated adhesion (By similarity)