Nuclear pore complex protein Nup50 (50 kDa nucleoporin) (Nuclear pore-associated protein 60 kDa-like) (Nucleoporin Nup50)
1_MAKRN 6_ AEKEL 11_ TDRNW 16_ DQEDE 21_ AEEVG 26_ TFSMA 31_ SEEVL 36_ KNRAI 41_ KKAKR 46_ RNVGF 51_ ESDTG 56_ GAFKG 61_ FKGLV 66_ VPSGG 71_ GRFSG 76_ FGSGA 81_ GGKPL 86_ EGLSN 91_ GNNIT 96_ SAPPF 101_ ASAKA 106_ AADPK 111_ VAFGS 116_ LAANG 121_ PTTLV 126_ DKVSN 131_ PKTNG 136_ DSQQP 141_ SSSGL 146_ ASSKA 151_ CVGNA 156_ YHKQL 161_ AALNC 166_ SVRDW 171_ IVKHV 176_ NTNPL 181_ CDLTP 186_ IFKDY 191_ EKYLA 196_ NIEQQ 201_ HGNSG 206_ RNSES 211_ ESNKV 216_ AAETQ 221_ SPSLF 226_ GSTKL 231_ QQEST 236_ FLFHG 241_ NKTED 246_ TPDKK 251_ MEVAS 256_ EKKTD 261_ PSSLG 266_ ATSAS 271_ FNFGK 276_ KVDSS 281_ VLGSL 286_ SSVPL 291_ TGFSF 296_ SPGNS 301_ SLFGK 306_ DTTQS 311_ KPVSS 316_ PFPTK 321_ PLEGQ 326_ AEGDS 331_ GECKG 336_ GDEEE 341_ NDEPP 346_ KVVVT 351_ EVKEE 356_ DAFYS 361_ KKCKL 366_ FYKKD 371_ NEFKE 376_ KGIGT 381_ LHLKP 386_ TANQK 391_ TQLLV 396_ RADTN 401_ LGNIL 406_ LNVLI 411_ PPNMP 416_ CTRTG 421_ KNNVL 426_ IVCVP 431_ NPPID 436_ EKNAT 441_ MPVTM 446_ LIRVK 451_ TSEDA 456_ DELHK 461_ILLEK
1: Component of the nuclear pore complex that has a direct role in nuclear protein import (PubMed:20016008). Actively displaces NLSs from importin-alpha, and facilitates disassembly of the importin-alpha:beta-cargo complex and importin recycling (PubMed:20016008). Interacts with regulatory proteins of cell cycle progression including CDKN1B (By similarity). This interaction is required for correct intracellular transport and degradation of CDKN1B (By similarity)