Integrator complex subunit 6 (Int6) (DBI-1) (Protein DDX26) (Protein deleted in cancer 1) (DICE1)
1_MPILL 6_ FLIDT 11_ SASMN 16_ QRSHL 21_ GTTYL 26_ DTAKG 31_ AVETF 36_ MKLRA 41_ RDPAS 46_ RGDRY 51_ MLVTF 56_ EEPPY 61_ AIKAG 66_ WKENH 71_ ATFMN 76_ ELKNL 81_ QAEGL 86_ TTLGQ 91_ SLRTA 96_ FDLLN 101_ LNRLV 106_ TGIDN 111_ YGQGR 116_ NPFFL 121_ EPAII 126_ ITITD 131_ GSKLT 136_ TTSGV 141_ QDELH 146_ LPLNS 151_ PLPGS 156_ ELTKE 161_ PFRWD 166_ QRLFA 171_ LVLRL 176_ PGTMS 181_ VESEQ 186_ LTGVP 191_ LDDSA 196_ ITPMC 201_ EVTGG 206_ RSYSV 211_ CSPRM 216_ LNQCL 221_ ESLVQ 226_ KVQSG 231_ VVINF 236_ EKAGP 241_ DPSPV 246_ EDGQP 251_ DISRP 256_ FGSQP 261_ WHSCH 266_ KLIYV 271_ RPNPK 276_ TGVPI 281_ GHWPV 286_ PESFW 291_ PDQNS 296_ PTLPP 301_ RTSHP 306_ VVKFS 311_ CTDCE 316_ PMVID 321_ KLPFD 326_ KYELE 331_ PSPLT 336_ QFILE 341_ RKSPQ 346_ TCWQV 351_ YVSNS 356_ AKYSE 361_ LGHPF 366_ GYLKA 371_ STALN 376_ CVNLF 381_ VMPYN 386_ YPVLL 391_ PLLDD 396_ LFKVH 401_ KAKPT 406_ LKWRQ 411_ SFESY 416_ LKTMP 421_ PYYLG 426_ PLKKA 431_ VRMMG 436_ APNLI 441_ ADSME 446_ YGLSY 451_ SVISY 456_ LKKLS 461_ QQAKI 466_ ESDRV 471_ IGSVG 476_ KKVVQ 481_ ETGIK 486_ VRSRS 491_ HGLSM 496_ AYRKD 501_ FQQLL 506_ QGISE 511_ DVPHR 516_ LLDLN 521_ MKEYT 526_ GFQVA 531_ LLNKD 536_ LKPQT 541_ FRNAY 546_ DIPRR 551_ NLLDH 556_ LTRMR 561_ SNLLK 566_ STRRF 571_ LKGQD 576_ EDQVH 581_ SVPIA 586_ QMGNY 591_ QEYLK 596_ QVPSP 601_ LRELD 606_ PDQPR 611_ RLHTF 616_ GNPFK 621_ LDKKG 626_ MMIDE 631_ ADEFV 636_ AGPQN 641_ KHKRP 646_ GEPNM 651_ QGIPK 656_ RRRCM 661_ SPLLR 666_ GRQQN 671_ PVVNN 676_ HIGGK 681_ GPPAP 686_ TTQAQ 691_ PDLIK 696_ PLPLH 701_ KISET 706_ TNDSI 711_ IHDVV 716_ ENHVA 721_ DQLSS 726_ DITPN 731_ AMDTE 736_ FSASS 741_ PASLL 746_ ERPTN 751_ HMEAL 756_ GHDHL 761_ GTNDL 766_ TVGGF 771_ LENHE 776_ EPRDK 781_ EQCAE 786_ ENIPA 791_ SSLNK 796_ GKKLM 801_ HCRSH 806_ EEVNT 811_ ELKAQ 816_ IMKEI 821_ RKPGR 826_ KYERI 831_ FTLLK 836_ HVQGS 841_ LQTRL 846_ IFLQN 851_ VIKEA 856_ SRFKK 861_ RMLIE 866_ QLENF 871_ LDEIH 876_ RRANQ 881_INHIN
1: Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes (PubMed:33243860, PubMed:34004147, PubMed:39504960). The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A and SUPT5H/SPT5, (2) degrading the exiting nascent RNA transcript via endonuclease activity and (3) promoting the release of Pol II from bound DNA (PubMed:33243860, PubMed:34004147, PubMed:38570683, PubMed:39504960). The integrator complex is also involved in terminating the synthesis of non-coding Pol II transcripts, such as enhancer RNAs (eRNAs), small nuclear RNAs (snRNAs), telomerase RNAs and long non-coding RNAs (lncRNAs) (PubMed:16239144). Within the integrator complex, INTS6 acts as a molecular adapter that promotes assembly of protein phosphatase 2A (PP2A) subunits to the integrator core complex, promoting recruitment of PP2A to transcription pause-release checkpoint (PubMed:33243860, PubMed:34004147). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the integrator complex (PubMed:23904267). May have a tumor suppressor role; an ectopic expression suppressing tumor cell growth (PubMed:15254679, PubMed:16239144)