BAG family molecular chaperone regulator 5 (BAG-5) (Bcl-2-associated athanogene 5)
1_MDMGN 6_ QHPSI 11_ SRLQE 16_ IQKEV 21_ KSVEQ 26_ QVIGF 31_ SGLSD 36_ DKNYK 41_ KLERI 46_ LTKQL 51_ FEIDS 56_ VDTEG 61_ KGDIQ 66_ QARKR 71_ AAQET 76_ ERLLK 81_ ELEQN 86_ ANHPH 91_ RIEIQ 96_ NIFEE 101_ AQSLV 106_ REKIV 111_ PFYNG 116_ GNCVT 121_ DEFEE 126_ GIQDI 131_ ILRLT 136_ HVKTG 141_ GKISL 146_ RKARY 151_ HTLTK 156_ ICAVQ 161_ EIIED 166_ CMKKQ 171_ PSLPL 176_ SEDAH 181_ PSVAK 186_ INFVM 191_ CEVNK 196_ ARGVL 201_ IALLM 206_ GVNNN 211_ ETCRH 216_ LSCVL 221_ SGLIA 226_ DLDAL 231_ DVCGR 236_ TEIRN 241_ YRREV 246_ VEDIN 251_ KLLKY 256_ LDLEE 261_ EADTT 266_ KAFDL 271_ RQNHS 276_ ILKIE 281_ KVLKR 286_ MREIK 291_ NELLQ 296_ AQNPS 301_ ELYLS 306_ SKTEL 311_ QGLIG 316_ QLDEV 321_ SLEKN 326_ PCIRE 331_ ARRRA 336_ VIEVQ 341_ TLITY 346_ IDLKE 351_ ALEKR 356_ KLFAC 361_ EEHPS 366_ HKAVW 371_ NVLGN 376_ LSEIQ 381_ GEVLS 386_ FDGNR 391_ TDKNY 396_ IRLEE 401_ LLTKQ 406_ LLALD 411_ AVDPQ 416_ GEEKC 421_ KAARK 426_ QAVRL 431_ AQNIL 436_ SYLDL 441_KSDEW
1: Co-chaperone for HSP/HSP70 proteins. It functions as a nucleotide-exchange factor promoting the release of ADP from HSP70, thereby activating HSP70-mediated protein refolding (PubMed:20223214). Has an essential role in maintaining proteostasis at junctional membrane complexes (JMC), where it may function as a scaffold between the HSPA8 chaperone and JMC proteins enabling correct, HSPA8-dependent JMC protein folding (By similarity). Inhibits both auto-ubiquitination of PRKN and ubiquitination of target proteins by PRKN (By similarity)