Protein argonaute-1 (Argonaute1) (hAgo1) (Argonaute RISC catalytic component 1) (Eukaryotic translation initiation factor 2C 1) (eIF-2C 1) (eIF2C 1) (Putative RNA-binding protein Q99)
1_MEAGP 6_ SGAAA 11_ GAYLP 16_ PLQQV 21_ FQAPR 26_ RPGIG 31_ TVGKP 36_ IKLLA 41_ NYFEV 46_ DIPKI 51_ DVYHY 56_ EVDIK 61_ PDKCP 66_ RRVNR 71_ EVVEY 76_ MVQHF 81_ KPQIF 86_ GDRKP 91_ VYDGK 96_ KNIYT 101_ VTALP 106_ IGNER 111_ VDFEV 116_ TIPGE 121_ GKDRI 126_ FKVSI 131_ KWLAI 136_ VSWRM 141_ LHEAL 146_ VSGQI 151_ PVPLE 156_ SVQAL 161_ DVAMR 166_ HLASM 171_ RYTPV 176_ GRSFF 181_ SPPEG 186_ YYHPL 191_ GGGRE 196_ VWFGF 201_ HQSVR 206_ PAMWK 211_ MMLNI 216_ DVSAT 221_ AFYKA 226_ QPVIE 231_ FMCEV 236_ LDIRN 241_ IDEQP 246_ KPLTD 251_ SQRVR 256_ FTKEI 261_ KGLKV 266_ EVTHC 271_ GQMKR 276_ KYRVC 281_ NVTRR 286_ PASHQ 291_ TFPLQ 296_ LESGQ 301_ TVECT 306_ VAQYF 311_ KQKYN 316_ LQLKY 321_ PHLPC 326_ LQVGQ 331_ EQKHT 336_ YLPLE 341_ VCNIV 346_ AGQRC 351_ IKKLT 356_ DNQTS 361_ TMIKA 366_ TARSA 371_ PDRQE 376_ EISRL 381_ MKNAS 386_ YNLDP 391_ YIQEF 396_ GIKVK 401_ DDMTE 406_ VTGRV 411_ LPAPI 416_ LQYGG 421_ RNRAI 426_ ATPNQ 431_ GVWDM 436_ RGKQF 441_ YNGIE 446_ IKVWA 451_ IACFA 456_ PQKQC 461_ REEVL 466_ KNFTD 471_ QLRKI 476_ SKDAG 481_ MPIQG 486_ QPCFC 491_ KYAQG 496_ ADSVE 501_ PMFRH 506_ LKNTY 511_ SGLQL 516_ IIVIL 521_ PGKTP 526_ VYAEV 531_ KRVGD 536_ TLLGM 541_ ATQCV 546_ QVKNV 551_ VKTSP 556_ QTLSN 561_ LCLKI 566_ NVKLG 571_ GINNI 576_ LVPHQ 581_ RSAVF 586_ QQPVI 591_ FLGAD 596_ VTHPP 601_ AGDGK 606_ KPSIT 611_ AVVGS 616_ MDAHP 621_ SRYCA 626_ TVRVQ 631_ RPRQE 636_ IIEDL 641_ SYMVR 646_ ELLIQ 651_ FYKST 656_ RFKPT 661_ RIIFY 666_ RDGVP 671_ EGQLP 676_ QILHY 681_ ELLAI 686_ RDACI 691_ KLEKD 696_ YQPGI 701_ TYIVV 706_ QKRHH 711_ TRLFC 716_ ADKNE 721_ RIGKS 726_ GNIPA 731_ GTTVD 736_ TNITH 741_ PFEFD 746_ FYLCS 751_ HAGIQ 756_ GTSRP 761_ SHYYV 766_ LWDDN 771_ RFTAD 776_ ELQIL 781_ TYQLC 786_ HTYVR 791_ CTRSV 796_ SIPAP 801_ AYYAR 806_ LVAFR 811_ ARYHL 816_ VDKEH 821_ DSGEG 826_ SHISG 831_ QSNGR 836_ DPQAL 841_ AKAVQ 846_ VHQDT 851_LRTMY
1: Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) or short interfering RNAs (siRNAs), and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. Also required for transcriptional gene silencing (TGS) of promoter regions which are complementary to bound short antigene RNAs (agRNAs)