Phospholipase A and acyltransferase 4 (EC 2.3.1.-) (EC 3.1.1.32) (EC 3.1.1.4) (HRAS-like suppressor 4) (HRSL4) (RAR-responsive protein TIG3) (Retinoic acid receptor responder protein 3) (Retinoid-inducible gene 1 protein) (Tazarotene-induced gene 3 protein)
1_MASPH 6_ QEPKP 11_ GDLIE 16_ IFRLG 21_ YEHWA 26_ LYIGD 31_ GYVIH 36_ LAPPS 41_ EYPGA 46_ GSSSV 51_ FSVLS 56_ NSAEV 61_ KRERL 66_ EDVVG 71_ GCCYR 76_ VNNSL 81_ DHEYQ 86_ PRPVE 91_ VIISS 96_ AKEMV 101_ GQKMK 106_ YSIVS 111_ RNCEH 116_ FVTQL 121_ RYGKS 126_ RCKQV 131_ EKAKV 136_ EVGVA 141_ TALGI 146_ LVVAG 151_ CSFAI 156_RRYQK
1: Exhibits both phospholipase A1/2 and acyltransferase activities (PubMed:19615464, PubMed:22605381, PubMed:22825852, PubMed:26503625). Shows phospholipase A1 (PLA1) and A2 (PLA2), catalyzing the calcium-independent release of fatty acids from the sn-1 or sn-2 position of glycerophospholipids (PubMed:19615464, PubMed:22605381, PubMed:22825852). For most substrates, PLA1 activity is much higher than PLA2 activity (PubMed:19615464). Shows O-acyltransferase activity, catalyzing the transfer of a fatty acyl group from glycerophospholipid to the hydroxyl group of lysophospholipid (PubMed:19615464). Shows N-acyltransferase activity, catalyzing the calcium-independent transfer of a fatty acyl group at the sn-1 position of phosphatidylcholine (PC) and other glycerophospholipids to the primary amine of phosphatidylethanolamine (PE), forming N-acylphosphatidylethanolamine (NAPE), which serves as precursor for N-acylethanolamines (NAEs) (PubMed:19615464, PubMed:22605381, PubMed:22825852). Promotes keratinocyte differentiation via activation of TGM1 (PubMed:17762858)