Ras-related protein Rab-21
1_MAAAG 6_ GGGGG 11_ AAAAG 16_ RAYSF 21_ KVVLL 26_ GEGCV 31_ GKTSL 36_ VLRYC 41_ ENKFN 46_ DKHIT 51_ TLQAS 56_ FLTKK 61_ LNIGG 66_ KRVNL 71_ AIWDT 76_ AGQER 81_ FHALG 86_ PIYYR 91_ DSNGA 96_ ILVYD 101_ ITDED 106_ SFQKV 111_ KNWVK 116_ ELRKM 121_ LGNEI 126_ CLCIV 131_ GNKID 136_ LEKER 141_ HVSIQ 146_ EAESY 151_ AESVG 156_ AKHYH 161_ TSAKQ 166_ NKGIE 171_ ELFLD 176_ LCKRM 181_ IETAQ 186_ VDERA 191_ KGNGS 196_ SQPGT 201_ ARRGV 206_ QIIDD 211_ EPQAQ 216_TSGGG
1: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:18804435, PubMed:25648148, PubMed:31455601). RAB21 is involved in membrane trafficking control (PubMed:18804435, PubMed:25648148). During the mitosis of adherent cells, controls the endosomal trafficking of integrins which is required for the successful completion of cytokinesis (PubMed:18804435). Regulates integrin internalization and recycling, but does not influence the traffic of endosomally translocated receptors in general (By similarity). As a result, may regulate cell adhesion and migration (By similarity). Involved in neurite growth (By similarity). Following SBF2/MTMT13-mediated activation in response to starvation-induced autophagy, binds to and regulates SNARE protein VAMP8 endolysosomal transport required for SNARE-mediated autophagosome-lysosome fusion (PubMed:25648148). Modulates protein levels of the cargo receptors TMED2 and TMED10, and required for appropriate Golgi localization of TMED10 (PubMed:31455601)