Ras-related protein Rab-22A (Rab-22)
1_MALRE 6_ LKVCL 11_ LGDTG 16_ VGKSS 21_ IVWRF 26_ VEDSF 31_ DPNIN 36_ PTIGA 41_ SFMTK 46_ TVQYQ 51_ NELHK 56_ FLIWD 61_ TAGQE 66_ RFRAL 71_ APMYY 76_ RGSAA 81_ AIIVY 86_ DITKE 91_ ETFST 96_ LKNWV 101_ KELRQ 106_ HGPPN 111_ IVVAI 116_ AGNKC 121_ DLIDV 126_ REVME 131_ RDAKD 136_ YADSI 141_ HAIFV 146_ ETSAK 151_ NAINI 156_ NELFI 161_ EISRR 166_ IPSTD 171_ ANLPS 176_ GGKGF 181_ KLRRQ 186_PSEPK
1: Plays a role in endocytosis and intracellular protein transport. Mediates trafficking of TF from early endosomes to recycling endosomes (PubMed:16537905). Required for NGF-mediated endocytosis of NTRK1, and subsequent neurite outgrowth (PubMed:21849477). Binds GTP and GDP and has low GTPase activity. Alternates between a GTP-bound active form and a GDP-bound inactive form (PubMed:16537905)