Biogenesis of lysosome-related organelles complex 1 subunit 6 (BLOC-1 subunit 6) (Pallid protein homolog) (Pallidin) (Syntaxin 13-interacting protein)
1_MSVPG 6_ PSSPD 11_ GALTR 16_ PPYCL 21_ EAGEP 26_ TPGLS 31_ DTSPD 36_ EGLIE 41_ DLTIE 46_ DKAVE 51_ QLAEG 56_ LLSHY 61_ LPDLQ 66_ RSKQA 71_ LQELT 76_ QNQVV 81_ LLDTL 86_ EQEIS 91_ KFKEC 96_ HSMLD 101_ INALF 106_ AEAKH 111_ YHAKL 116_ VNIRK 121_ EMLML 126_ HEKTS 131_ KLKKR 136_ ALKLQ 141_ QKRQK 146_ EELER 151_ EQQRE 156_ KEFER 161_ EKQLT 166_ARPAK
1: Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. May play a role in intracellular vesicle trafficking, particularly in the vesicle-docking and fusion process