Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (Brain cyclic nucleotide-gated channel 2) (BCNG-2)
1_MDARG 6_ GGGRP 11_ GESPG 16_ ATPAP 21_ GPPPP 26_ PPPAP 31_ PQQQP 36_ PPPPP 41_ PAPPP 46_ GPGPA 51_ PPQHP 56_ PRAEA 61_ LPPEA 66_ ADEGG 71_ PRGRL 76_ RSRDS 81_ SCGRP 86_ GTPGA 91_ ASTAK 96_ GSPNG 101_ ECGRG 106_ EPQCS 111_ PAGPE 116_ GPARG 121_ PKVSF 126_ SCRGA 131_ ASGPA 136_ PGPGP 141_ AEEAG 146_ SEEAG 151_ PAGEP 156_ RGSQA 161_ SFMQR 166_ QFGAL 171_ LQPGV 176_ NKFSL 181_ RMFGS 186_ QKAVE 191_ REQER 196_ VKSAG 201_ AWIIH 206_ PYSDF 211_ RFYWD 216_ FTMLL 221_ FMVGN 226_ LIIIP 231_ VGITF 236_ FKDET 241_ TAPWI 246_ VFNVV 251_ SDTFF 256_ LMDLV 261_ LNFRT 266_ GIVIE 271_ DNTEI 276_ ILDPE 281_ KIKKK 286_ YLRTW 291_ FVVDF 296_ VSSIP 301_ VDYIF 306_ LIVEK 311_ GIDSE 316_ VYKTA 321_ RALRI 326_ VRFTK 331_ ILSLL 336_ RLLRL 341_ SRLIR 346_ YIHQW 351_ EEIFH 356_ MTYDL 361_ ASAVM 366_ RICNL 371_ ISMML 376_ LLCHW 381_ DGCLQ 386_ FLVPM 391_ LQDFP 396_ RNCWV 401_ SINGM 406_ VNHSW 411_ SELYS 416_ FALFK 421_ AMSHM 426_ LCIGY 431_ GRQAP 436_ ESMTD 441_ IWLTM 446_ LSMIV 451_ GATCY 456_ AMFIG 461_ HATAL 466_ IQSLD 471_ SSRRQ 476_ YQEKY 481_ KQVEQ 486_ YMSFH 491_ KLPAD 496_ FRQKI 501_ HDYYE 506_ HRYQG 511_ KMFDE 516_ DSILG 521_ ELNGP 526_ LREEI 531_ VNFNC 536_ RKLVA 541_ SMPLF 546_ ANADP 551_ NFVTA 556_ MLTKL 561_ KFEVF 566_ QPGDY 571_ IIREG 576_ TIGKK 581_ MYFIQ 586_ HGVVS 591_ VLTKG 596_ NKEMK 601_ LSDGS 606_ YFGEI 611_ CLLTR 616_ GRRTA 621_ SVRAD 626_ TYCRL 631_ YSLSV 636_ DNFNE 641_ VLEEY 646_ PMMRR 651_ AFETV 656_ AIDRL 661_ DRIGK 666_ KNSIL 671_ LHKVQ 676_ HDLNS 681_ GVFNN 686_ QENAI 691_ IQEIV 696_ KYDRE 701_ MVQQA 706_ ELGQR 711_ VGLFP 716_ PPPPP 721_ PQVTS 726_ AIATL 731_ QQAAA 736_ MSFCP 741_ QVARP 746_ LVGPL 751_ ALGSP 756_ RLVRR 761_ PPPGP 766_ APAAA 771_ SPGPP 776_ PPASP 781_ PGAPA 786_ SPRAP 791_ RTSPY 796_ GGLPA 801_ APLAG 806_ PALPA 811_ RRLSR 816_ ASRPL 821_ SASQP 826_ SLPHG 831_ APGPA 836_ ASTRP 841_ ASSST 846_ PRLGP 851_ TPAAR 856_ AAAPS 861_ PDRRD 866_ SASPG 871_ AAGGL 876_ DPQDS 881_ARSRL
1: Hyperpolarization-activated ion channel that is permeable to sodium and potassium ions. Displays lower selectivity for K(+) over Na(+) ions (PubMed:10228147, PubMed:22006928). Contributes to the native pacemaker currents in heart (If) and in neurons (Ih) (PubMed:10228147, PubMed:10524219). Can also transport ammonium in the distal nephron (By similarity). Involved in the initiation of neuropathic pain in sensory neurons (By similarity)