Serine/threonine-protein kinase TAO2 (EC 2.7.11.1) (Kinase from chicken homolog C) (hKFC-C) (Prostate-derived sterile 20-like kinase 1) (PSK-1) (PSK1) (Prostate-derived STE20-like kinase 1) (Thousand and one amino acid protein kinase 2)
1_MPAGG 6_ RAGSL 11_ KDPDV 16_ AELFF 21_ KDDPE 26_ KLFSD 31_ LREIG 36_ HGSFG 41_ AVYFA 46_ RDVRN 51_ SEVVA 56_ IKKMS 61_ YSGKQ 66_ SNEKW 71_ QDIIK 76_ EVRFL 81_ QKLRH 86_ PNTIQ 91_ YRGCY 96_ LREHT 101_ AWLVM 106_ EYCLG 111_ SASDL 116_ LEVHK 121_ KPLQE 126_ VEIAA 131_ VTHGA 136_ LQGLA 141_ YLHSH 146_ NMIHR 151_ DVKAG 156_ NILLS 161_ EPGLV 166_ KLGDF 171_ GSASI 176_ MAPAN 181_ SFVGT 186_ PYWMA 191_ PEVIL 196_ AMDEG 201_ QYDGK 206_ VDVWS 211_ LGITC 216_ IELAE 221_ RKPPL 226_ FNMNA 231_ MSALY 236_ HIAQN 241_ ESPVL 246_ QSGHW 251_ SEYFR 256_ NFVDS 261_ CLQKI 266_ PQDRP 271_ TSEVL 276_ LKHRF 281_ VLRER 286_ PPTVI 291_ MDLIQ 296_ RTKDA 301_ VRELD 306_ NLQYR 311_ KMKKI 316_ LFQEA 321_ PNGPG 326_ AEAPE 331_ EEEEA 336_ EPYMH 341_ RAGTL 346_ TSLES 351_ SHSVP 356_ SMSIS 361_ ASSQS 366_ SSVNS 371_ LADAS 376_ DNEEE 381_ EEEEE 386_ EEEEE 391_ EEGPE 396_ AREMA 401_ MMQEG 406_ EHTVT 411_ SHSSI 416_ IHRLP 421_ GSDNL 426_ YDDPY 431_ QPEIT 436_ PSPLQ 441_ PPAAP 446_ APTST 451_ TSSAR 456_ RRAYC 461_ RNRDH 466_ FATIR 471_ TASLV 476_ SRQIQ 481_ EHEQD 486_ SALRE 491_ QLSGY 496_ KRMRR 501_ QHQKQ 506_ LLALE 511_ SRLRG 516_ EREEH 521_ SARLQ 526_ RELEA 531_ QRAGF 536_ GAEAE 541_ KLARR 546_ HQAIG 551_ EKEAR 556_ AAQAE 561_ ERKFQ 566_ QHILG 571_ QQKKE 576_ LAALL 581_ EAQKR 586_ TYKLR 591_ KEQLK 596_ EELQE 601_ NPSTP 606_ KREKA 611_ EWLLR 616_ QKEQL 621_ QQCQA 626_ EEEAG 631_ LLRRQ 636_ RQYFE 641_ LQCRQ 646_ YKRKM 651_ LLARH 656_ SLDQD 661_ LLRED 666_ LNKKQ 671_ TQKDL 676_ ECALL 681_ LRQHE 686_ ATREL 691_ ELRQL 696_ QAVQR 701_ TRAEL 706_ TRLQH 711_ QTELG 716_ NQLEY 721_ NKRRE 726_ QELRQ 731_ KHAAQ 736_ VRQQP 741_ KSLKV 746_ RAGQR 751_ PPGLP 756_ LPIPG 761_ ALGPP 766_ NTGTP 771_ IEQQP 776_ CSPGQ 781_ EAVLD 786_ QRMLG 791_ EEEEA 796_ VGERR 801_ ILGKE 806_ GATLE 811_ PKQQR 816_ ILGEE 821_ SGAPS 826_ PSPQK 831_ HGSLV 836_ DEEVW 841_ GLPEE 846_ IEELR 851_ VPSLV 856_ PQERS 861_ IVGQE 866_ EAGTW 871_ SLWGK 876_ EDESL 881_ LDEEF 886_ ELGWV 891_ QGPAL 896_ TPVPE 901_ EEEEE 906_ EEGAP 911_ IGTPR 916_ DPGDG 921_ CPSPD 926_ IPPEP 931_ PPTHL 936_ RPCPA 941_ SQLPG 946_ LLSHG 951_ LLAGL 956_ SFAVG 961_ SSSGL 966_ LPLLL 971_ LLLLP 976_ LLAAQ 981_ GGGGL 986_ QAALL 991_ ALEVG 996_ LVGLG 1001_ ASYLL 1006_ LCTAL 1011_ HLPSS 1016_ LFLLL 1021_ AQGTA 1026_ LGAVL 1031_ GLSWR 1036_ RGLMG 1041_ VPLGL 1046_ GAAWL 1051_ LAWPG 1056_ LALPL 1061_ VAMAA 1066_ GGRWV 1071_ RQQGP 1076_ RVRRG 1081_ ISRLW 1086_ LRVLL 1091_ RLSPM 1096_ AFRAL 1101_ QGCGA 1106_ VGDRG 1111_ LFALY 1116_ PKTNK 1121_ DGFRS 1126_ RLPVP 1131_ GPRRR 1136_ NPRTT 1141_ QHPLA 1146_ LLARV 1151_ WVLCK 1156_ GWNWR 1161_ LARAS 1166_ QGLAS 1171_ HLPPW 1176_ AIHTL 1181_ ASWGL 1186_ LRGER 1191_ PTRIP 1196_ RLLPR 1201_ SQRQL 1206_ GPPAS 1211_ RQPLP 1216_ GTLAG 1221_ RRSRT 1226_RQSRA
1: Serine/threonine-protein kinase involved in different processes such as membrane blebbing and apoptotic bodies formation DNA damage response and MAPK14/p38 MAPK stress-activated MAPK cascade. Phosphorylates itself, MBP, activated MAPK8, MAP2K3, MAP2K6 and tubulins. Activates the MAPK14/p38 MAPK signaling pathway through the specific activation and phosphorylation of the upstream MAP2K3 and MAP2K6 kinases. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Isoform 1, but not isoform 2, plays a role in apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation. This function, which requires the activation of MAPK8/JNK and nuclear localization of C-terminally truncated isoform 1, may be linked to the mitochondrial CASP9-associated death pathway. Isoform 1 binds to microtubules and affects their organization and stability independently of its kinase activity. Prevents MAP3K7-mediated activation of CHUK, and thus NF-kappa-B activation, but not that of MAPK8/JNK. May play a role in the osmotic stress-MAPK8 pathway. Isoform 2, but not isoform 1, is required for PCDH8 endocytosis. Following homophilic interactions between PCDH8 extracellular domains, isoform 2 phosphorylates and activates MAPK14/p38 MAPK which in turn phosphorylates isoform 2. This process leads to PCDH8 endocytosis and CDH2 cointernalization. Both isoforms are involved in MAPK14 phosphorylation