Myelin transcription factor 1-like protein (MyT1-L) (MyT1L)
1_MEVDT 6_ EEKRH 11_ RTRSK 16_ GVRVP 21_ VEPAI 26_ QELFS 31_ CPTPG 36_ CDGSG 41_ HVSGK 46_ YARHR 51_ SVYGC 56_ PLAKK 61_ RKTQD 66_ KQPQE 71_ PAPKR 76_ KPFAV 81_ KADSS 86_ SVDEC 91_ DDSDG 96_ TEDMD 101_ EKEED 106_ EGEEY 111_ SEDND 116_ EPGDE 121_ DEEDE 126_ EGDRE 131_ EEEEI 136_ EEEDE 141_ DDDED 146_ GEDVE 151_ DEEEE 156_ EEEEE 161_ EEEEE 166_ EENED 171_ HQMNC 176_ HNTRI 181_ MQDTE 186_ KDDNN 191_ NDEYD 196_ NYDEL 201_ VAKSL 206_ LNLGK 211_ IAEDA 216_ AYRAR 221_ TESEM 226_ NSNTS 231_ NSLED 236_ DSDKN 241_ ENLGR 246_ KSELS 251_ LDLDS 256_ DVVRE 261_ TVDSL 266_ KLLAQ 271_ GHGVV 276_ LSENM 281_ NDRNY 286_ ADSMS 291_ QQDSR 296_ NMNYV 301_ MLGKP 306_ MNNGL 311_ MEKMV 316_ EESDE 321_ EVCLS 326_ SLECL 331_ RNQCF 336_ DLARK 341_ LSETN 346_ PQERN 351_ PQQNM 356_ NIRQH 361_ VRPEE 366_ DFPGR 371_ TPDRN 376_ YSDML 381_ NLMRL 386_ EEQLS 391_ PRSRV 396_ FASCA 401_ KEDGC 406_ HERDD 411_ DTTSV 416_ NSDRS 421_ EEVFD 426_ MTKGN 431_ LTLLE 436_ KAIAL 441_ ETERA 446_ KAMRE 451_ KMAME 456_ AGRRD 461_ NMRSY 466_ EDQSP 471_ RQLPG 476_ EDRKP 481_ KSSDS 486_ HVKKP 491_ YYGKD 496_ PSRTE 501_ KKESK 506_ CPTPG 511_ CDGTG 516_ HVTGL 521_ YPHHR 526_ SLSGC 531_ PHKDR 536_ VPPEI 541_ LAMHE 546_ SVLKC 551_ PTPGC 556_ TGRGH 561_ VNSNR 566_ NSHRS 571_ LSGCP 576_ IAAAE 581_ KLAKA 586_ QEKHQ 591_ SCDVS 596_ KSSQA 601_ SDRVL 606_ RPMCF 611_ VKQLE 616_ IPQYG 621_ YRNNV 626_ PTTTP 631_ RSNLA 636_ KELEK 641_ YSKTS 646_ FEYNS 651_ YDNHT 656_ YGKRA 661_ IAPKV 666_ QTRDI 671_ SPKGY 676_ DDAKR 681_ YCKDP 686_ SPSSS 691_ STSSY 696_ APSSS 701_ SNLSC 706_ GGGSS 711_ ASSTC 716_ SKSSF 721_ DYTHD 726_ MEAAH 731_ MAATA 736_ ILNLS 741_ TRCRE 746_ MPQNL 751_ STKPQ 756_ DLCAT 761_ RNPDM 766_ EVDEN 771_ GTLDL 776_ SMNKQ 781_ RPRDS 786_ CCPIL 791_ TPLEP 796_ MSPQQ 801_ QAVMN 806_ NRCFQ 811_ LGEGD 816_ CWDLP 821_ VDYTK 826_ MKPRR 831_ IDEDE 836_ SKDIT 841_ PEDLD 846_ PFQEA 851_ LEERR 856_ YPGEV 861_ TIPSP 866_ KPKYP 871_ QCKES 876_ KKDLI 881_ TLSGC 886_ PLADK 891_ SIRSM 896_ LATSS 901_ QELKC 906_ PTPGC 911_ DGSGH 916_ ITGNY 921_ ASHRS 926_ LSGCP 931_ RAKKS 936_ GIRIA 941_ QSKED 946_ KEDQE 951_ PIRCP 956_ VPGCD 961_ GQGHI 966_ TGKYA 971_ SHRSA 976_ SGCPL 981_ AAKRQ 986_ KDGYL 991_ NGSQF 996_ SWKSV 1001_ KTEGM 1006_ SCPTP 1011_ GCDGS 1016_ GHVSG 1021_ SFLTH 1026_ RSLSG 1031_ CPRAT 1036_ SAMKK 1041_ AKLSG 1046_ EQMLT 1051_ IKQRA 1056_ SNGIE 1061_ NDEEI 1066_ KQLDE 1071_ EIKEL 1076_ NESNS 1081_ QMEAD 1086_ MIKLR 1091_ TQITT 1096_ MESNL 1101_ KTIEE 1106_ ENKVI 1111_ EQQNE 1116_ SLLHE 1121_ LANLS 1126_ QSLIH 1131_ SLANI 1136_ QLPHM 1141_ DPINE 1146_ QNFDA 1151_ YVTTL 1156_ TEMYT 1161_ NQDRY 1166_ QSPEN 1171_ KALLE 1176_ NIKQA 1181_VRGIQ
1: Transcription factor that plays a key role in neuronal differentiation by specifically repressing expression of non-neuronal genes during neuron differentiation. In contrast to other transcription repressors that inhibit specific lineages, mediates repression of multiple differentiation programs. Also represses expression of negative regulators of neurogenesis, such as members of the Notch signaling pathway, including HES1. The combination of three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro. Directly binds the 5'-AAGTT-3' core motif present on the promoter of target genes and represses transcription by recruiting a multiprotein complex containing SIN3B. The 5'-AAGTT-3' core motif is absent from the promoter of neural genes