Neurexin-1 (Neurexin I-alpha) (Neurexin-1-alpha)
1_MGTAL 6_ LQRGG 11_ CFLLC 16_ LSLLL 21_ LGCWA 26_ ELGSG 31_ LEFPG 36_ AEGQW 41_ TRFPK 46_ WNACC 51_ ESEMS 56_ FQLKT 61_ RSARG 66_ LVLYF 71_ DDEGF 76_ CDFLE 81_ LILTR 86_ GGRLQ 91_ LSFSI 96_ FCAEP 101_ ATLLA 106_ DTPVN 111_ DGAWH 116_ SVRIR 121_ RQFRN 126_ TTLFI 131_ DQVEA 136_ KWVEV 141_ KSKRR 146_ DMTVF 151_ SGLFV 156_ GGLPP 161_ ELRAA 166_ ALKLT 171_ LASVR 176_ EREPF 181_ KGWIR 186_ DVRVN 191_ SSQVL 196_ PVDSG 201_ EVKLD 206_ DEPPN 211_ SGGGS 216_ PCEAG 221_ EEGEG 226_ GVCLN 231_ GGVCS 236_ VVDDQ 241_ AVCDC 246_ SRTGF 251_ RGKDC 256_ SQEDN 261_ NVEGL 266_ AHLMM 271_ GDQGK 276_ SKGKE 281_ EYIAT 286_ FKGSE 291_ YFCYD 296_ LSQNP 301_ IQSSS 306_ DEITL 311_ SFKTL 316_ QRNGL 321_ MLHTG 326_ KSADY 331_ VNLAL 336_ KNGAV 341_ SLVIN 346_ LGSGA 351_ FEALV 356_ EPVNG 361_ KFNDN 366_ AWHDV 371_ KVTRN 376_ LRQHS 381_ GIGHA 386_ MVTIS 391_ VDGIL 396_ TTTGY 401_ TQEDY 406_ TMLGS 411_ DDFFY 416_ VGGSP 421_ STADL 426_ PGSPV 431_ SNNFM 436_ GCLKE 441_ VVYKN 446_ NDVRL 451_ ELSRL 456_ AKQGD 461_ PKMKI 466_ HGVVA 471_ FKCEN 476_ VATLD 481_ PITFE 486_ TPESF 491_ ISLPK 496_ WNAKK 501_ TGSIS 506_ FDFRT 511_ TEPNG 516_ LILFS 521_ HGKPR 526_ HQKDA 531_ KHPQM 536_ IKVDF 541_ FAIEM 546_ LDGHL 551_ YLLLD 556_ MGSGT 561_ IKIKA 566_ LLKKV 571_ NDGEW 576_ YHVDF 581_ QRDGR 586_ SGTIS 591_ VNTLR 596_ TPYTA 601_ PGESE 606_ ILDLD 611_ DELYL 616_ GGLPE 621_ NKAGL 626_ VFPTE 631_ VWTAL 636_ LNYGY 641_ VGCIR 646_ DLFID 651_ GQSKD 656_ IRQMA 661_ EVQST 666_ AGVKP 671_ SCSKE 676_ TAKPC 681_ LSNPC 686_ KNNGM 691_ CRDGW 696_ NRYVC 701_ DCSGT 706_ GYLGR 711_ SCERE 716_ ATVLS 721_ YDGSM 726_ FMKIQ 731_ LPVVM 736_ HTEAE 741_ DVSLR 746_ FRSQR 751_ AYGIL 756_ MATTS 761_ RDSAD 766_ TLRLE 771_ LDAGR 776_ VKLTV 781_ NLDCI 786_ RINCN 791_ SSKGP 796_ ETLFA 801_ GYNLN 806_ DNEWH 811_ TVRVV 816_ RRGKS 821_ LKLTV 826_ DDQQA 831_ MTGQM 836_ AGDHT 841_ RLEFH 846_ NIETG 851_ IITER 856_ RYLSS 861_ VPSNF 866_ IGHLQ 871_ SLTFN 876_ GMAYI 881_ DLCKN 886_ GDIDY 891_ CELNA 896_ RFGFR 901_ NIIAD 906_ PVTFK 911_ TKSSY 916_ VALAT 921_ LQAYT 926_ SMHLF 931_ FQFKT 936_ TSLDG 941_ LILYN 946_ SGDGN 951_ DFIVV 956_ ELVKG 961_ YLHYV 966_ FDLGN 971_ GANLI 976_ KGSSN 981_ KPLND 986_ NQWHN 991_ VMISR 996_ DTSNL 1001_ HTVKI 1006_ DTKIT 1011_ TQITA 1016_ GARNL 1021_ DLKSD 1026_ LYIGG 1031_ VAKET 1036_ YKSLP 1041_ KLVHA 1046_ KEGFQ 1051_ GCLAS 1056_ VDLNG 1061_ RLPDL 1066_ ISDAL 1071_ FCNGQ 1076_ IERGC 1081_ EGPST 1086_ TCQED 1091_ SCSNQ 1096_ GVCLQ 1101_ QWDGF 1106_ SCDCS 1111_ MTSFS 1116_ GPLCN 1121_ DPGTT 1126_ YIFSK 1131_ GGGQI 1136_ TYKWP 1141_ PNDRP 1146_ STRAD 1151_ RLAIG 1156_ FSTVQ 1161_ KEAVL 1166_ VRVDS 1171_ SSGLG 1176_ DYLEL 1181_ HIHQG 1186_ KIGVK 1191_ FNVGT 1196_ DDIAI 1201_ EESNA 1206_ IINDG 1211_ KYHVV 1216_ RFTRS 1221_ GGNAT 1226_ LQVDS 1231_ WPVIE 1236_ RYPAG 1241_ RQLTI 1246_ FNSQA 1251_ TIIIG 1256_ GKEQG 1261_ QPFQG 1266_ QLSGL 1271_ YYNGL 1276_ KVLNM 1281_ AAEND 1286_ ANIAI 1291_ VGNVR 1296_ LVGEV 1301_ PSSMT 1306_ TESTA 1311_ TAMQS 1316_ EMSTS 1321_ IMETT 1326_ TTLAT 1331_ STARR 1336_ GKPPT 1341_ KEPIS 1346_ QTTDD 1351_ ILVAS 1356_ AECPS 1361_ DDEDI 1366_ DPCEP 1371_ SSGGL 1376_ ANPTR 1381_ AGGRE 1386_ PYPGS 1391_ AEVIR 1396_ ESSST 1401_ TGMVV 1406_ GIVAA 1411_ AALCI 1416_ LILLY 1421_ AMYKY 1426_ RNRDE 1431_ GSYHV 1436_ DESRN 1441_ YISNS 1446_ AQSNG 1451_ AVVKE 1456_ KQPSS 1461_ AKSSN 1466_ KNKKN 1471_KDKEY
1: Cell surface protein involved in cell-cell-interactions, exocytosis of secretory granules and regulation of signal transmission. Function is isoform-specific. Alpha-type isoforms have a long N-terminus with six laminin G-like domains and play an important role in synaptic signal transmission. Alpha-type isoforms play a role in the regulation of calcium channel activity and Ca(2+)-triggered neurotransmitter release at synapses and at neuromuscular junctions. They play an important role in Ca(2+)-triggered exocytosis of secretory granules in pituitary gland. They may affect their functions at synapses and in endocrine cells via their interactions with proteins from the exocytotic machinery. Likewise, alpha-type isoforms play a role in regulating the activity of postsynaptic NMDA receptors, a subtype of glutamate-gated ion channels. Both alpha-type and beta-type isoforms may play a role in the formation or maintenance of synaptic junctions via their interactions (via the extracellular domains) with neuroligin family members, CBLN1 or CBLN2. In vitro, triggers the de novo formation of presynaptic structures. May be involved in specification of excitatory synapses. Alpha-type isoforms were first identified as receptors for alpha-latrotoxin from spider venom