Ras-related protein Rab-23
1_MLEED 6_ MEVAI 11_ KMVVV 16_ GNGAV 21_ GKSSM 26_ IQRYC 31_ KGIFT 36_ KDYKK 41_ TIGVD 46_ FLERQ 51_ IQVND 56_ EDVRL 61_ MLWDT 66_ AGQEE 71_ FDAIT 76_ KAYYR 81_ GAQAC 86_ VLVFS 91_ TTDRE 96_ SFEAV 101_ SSWRE 106_ KVVAE 111_ VGDIP 116_ TVLVQ 121_ NKIDL 126_ LDDSC 131_ IKNEE 136_ AEALA 141_ KRLKL 146_ RFYRT 151_ SVKED 156_ LNVNE 161_ VFKYL 166_ AEKYL 171_ QKLKQ 176_ QIAED 181_ PELTH 186_ SSSNK 191_ IGVFN 196_ TSGGS 201_ HSGQN 206_ SGTLN 211_ GGDVI 216_ NLRPN 221_ KQRTK 226_ KNRNP 231_FSSCS
1: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Together with SUFU, prevents nuclear import of GLI1, and thereby inhibits GLI1 transcription factor activity. Regulates GLI1 in differentiating chondrocytes. Likewise, regulates GLI3 proteolytic processing and modulates GLI2 and GLI3 transcription factor activity. Plays a role in autophagic vacuole assembly, and mediates defense against pathogens, such as S.aureus, by promoting their capture by autophagosomes that then merge with lysosomes