Malignant T-cell-amplified sequence 1 (MCT-1) (Multiple copies T-cell malignancies)
1_MFKKF 6_ DEKEN 11_ VSNCI 16_ QLKTS 21_ VIKGI 26_ KNQLI 31_ EQFPG 36_ IEPWL 41_ NQIMP 46_ KKDPV 51_ KIVRC 56_ HEHIE 61_ ILTVN 66_ GELLF 71_ FRQRE 76_ GPFYP 81_ TLRLL 86_ HKYPF 91_ ILPHQ 96_ QVDKG 101_ AIKFV 106_ LSGAN 111_ IMCPG 116_ LTSPG 121_ AKLYP 126_ AAVDT 131_ IVAIM 136_ AEGKQ 141_ HALCV 146_ GVMKM 151_ SAEDI 156_ EKVNK 161_ GIGIE 166_ NIHYL 171_ NDGLW 176_HMKTY
1: Translation regulator forming a complex with DENR to promote translation reinitiation. Translation reinitiation is the process where the small ribosomal subunit remains attached to the mRNA following termination of translation of a regulatory upstream ORF (uORF), and resume scanning on the same mRNA molecule to initiate translation of a downstream ORF, usually the main ORF (mORF). The MCTS1/DENR complex is pivotal to two linked mechanisms essential for translation reinitiation. Firstly, the dissociation of deacylated tRNAs from post-termination 40S ribosomal complexes during ribosome recycling. Secondly, the recruitment in an EIF2-independent manner of aminoacylated initiator tRNA to P site of 40S ribosomes for a new round of translation (PubMed:16982740, PubMed:20713520, PubMed:37875108). This regulatory mechanism governs the translation of more than 150 genes which translation reinitiation is MCTS1/DENR complex-dependent (PubMed:16982740, PubMed:20713520, PubMed:37875108). Consequently, modulates various unrelated biological processes including cell cycle regulation and DNA damage signaling and repair (PubMed:10440924, PubMed:11709712, PubMed:12637315, PubMed:15897892, PubMed:16322206, PubMed:17016429, PubMed:17416211, PubMed:9766643). Notably, it positively regulates interferon gamma immunity to mycobacteria by enhancing the translation of JAK2 (PubMed:37875108)