Long-chain-fatty-acid--CoA ligase 5 (EC 6.2.1.3) (Arachidonate--CoA ligase) (EC 6.2.1.15) (Long-chain acyl-CoA synthetase 5) (LACS 5)
1_MLFIF 6_ NFLFS 11_ PLPTP 16_ ALICI 21_ LTFGA 26_ AIFLW 31_ LITRP 36_ QPVLP 41_ LLDLN 46_ NQSVG 51_ IEGGA 56_ RKGVS 61_ QKNND 66_ LTSCC 71_ FSDAK 76_ TMYEV 81_ FQRGL 86_ AVSDN 91_ GPCLG 96_ YRKPN 101_ QPYRW 106_ LSYKQ 111_ VSDRA 116_ EYLGS 121_ CLLHK 126_ GYKSS 131_ PDQFV 136_ GIFAQ 141_ NRPEW 146_ IISEL 151_ ACYTY 156_ SMVAV 161_ PLYDT 166_ LGPEA 171_ IVHIV 176_ NKADI 181_ AMVIC 186_ DTPQK 191_ ALVLI 196_ GNVEK 201_ GFTPS 206_ LKVII 211_ LMDPF 216_ DDDLK 221_ QRGEK 226_ SGIEI 231_ LSLYD 236_ AENLG 241_ KEHFR 246_ KPVPP 251_ SPEDL 256_ SVICF 261_ TSGTT 266_ GDPKG 271_ AMITH 276_ QNIVS 281_ NAAAF 286_ LKCVE 291_ HAYEP 296_ TPDDV 301_ AISYL 306_ PLAHM 311_ FERIV 316_ QAVVY 321_ SCGAR 326_ VGFFQ 331_ GDIRL 336_ LADDM 341_ KTLKP 346_ TLFPA 351_ VPRLL 356_ NRIYD 361_ KVQNE 366_ AKTPL 371_ KKFLL 376_ KLAVS 381_ SKFKE 386_ LQKGI 391_ IRHDS 396_ FWDKL 401_ IFAKI 406_ QDSLG 411_ GRVRV 416_ IVTGA 421_ APMST 426_ SVMTF 431_ FRAAM 436_ GCQVY 441_ EAYGQ 446_ TECTG 451_ GCTFT 456_ LPGDW 461_ TSGHV 466_ GVPLA 471_ CNYVK 476_ LEDVA 481_ DMNYF 486_ TVNNE 491_ GEVCI 496_ KGTNV 501_ FKGYL 506_ KDPEK 511_ TQEAL 516_ DSDGW 521_ LHTGD 526_ IGRWL 531_ PNGTL 536_ KIIDR 541_ KKNIF 546_ KLAQG 551_ EYIAP 556_ EKIEN 561_ IYNRS 566_ QPVLQ 571_ IFVHG 576_ ESLRS 581_ SLVGV 586_ VVPDT 591_ DVLPS 596_ FAAKL 601_ GVKGS 606_ FEELC 611_ QNQVV 616_ REAIL 621_ EDLQK 626_ IGKES 631_ GLKTF 636_ EQVKA 641_ IFLHP 646_ EPFSI 651_ ENGLL 656_ TPTLK 661_ AKRGE 666_ LSKYF 671_ RTQID 676_SLYEH
1: Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation (PubMed:17681178, PubMed:22633490, PubMed:24269233, PubMed:33191500). ACSL5 may activate fatty acids from exogenous sources for the synthesis of triacylglycerol destined for intracellular storage (By similarity). Utilizes a wide range of saturated fatty acids with a preference for C16-C18 unsaturated fatty acids (By similarity). It was suggested that it may also stimulate fatty acid oxidation (By similarity). At the villus tip of the crypt-villus axis of the small intestine may sensitize epithelial cells to apoptosis specifically triggered by the death ligand TRAIL. May have a role in the survival of glioma cells