Palmitoyltransferase ZDHHC8 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 8) (DHHC-8) (Zinc finger protein 378)
1_MPRSP 6_ GTRLK 11_ PAKYI 16_ PVATA 21_ AALLV 26_ GSSTL 31_ FFVFT 36_ CPWLT 41_ RAVSP 46_ AVPVY 51_ NGIIF 56_ LFVLA 61_ NFSMA 66_ TFMDP 71_ GVFPR 76_ ADEDE 81_ DKEDD 86_ FRAPL 91_ YKNVD 96_ VRGIQ 101_ VRMKW 106_ CATCH 111_ FYRPP 116_ RCSHC 121_ SVCDN 126_ CVEDF 131_ DHHCP 136_ WVNNC 141_ IGRRN 146_ YRYFF 151_ LFLLS 156_ LSAHM 161_ VGVVA 166_ FGLVY 171_ VLNHA 176_ EGLGA 181_ AHTTI 186_ TMAVM 191_ CVAGL 196_ FFIPV 201_ IGLTG 206_ FHVVL 211_ VTRGR 216_ TTNEQ 221_ VTGKF 226_ RGGVN 231_ PFTRG 236_ CCGNV 241_ EHVLC 246_ SPLAP 251_ RYVVE 256_ PPRLP 261_ LAVSL 266_ KPPFL 271_ RPELL 276_ DRAAP 281_ LKVKL 286_ SDNGL 291_ KAGLG 296_ RSKSK 301_ GSLDR 306_ LDEKP 311_ LDLGP 316_ PLPPK 321_ IEAGT 326_ FSSDL 331_ QTPRP 336_ GSAES 341_ ALSVQ 346_ RTSPP 351_ TPAMY 356_ KFRPA 361_ FPTGP 366_ KVPFC 371_ GPGEQ 376_ VPGPD 381_ SLTLG 386_ DDSIR 391_ SLDFV 396_ SEPSL 401_ DLPDY 406_ GPGGL 411_ HAAYP 416_ PSPPL 421_ SASDA 426_ FSGAL 431_ RSLSL 436_ KASSR 441_ RGGDH 446_ VALQP 451_ LRSEG 456_ GPPTP 461_ HRSIF 466_ APHAL 471_ PNRNG 476_ SLSYD 481_ SLLNP 486_ GSPGG 491_ HACPA 496_ HPAVG 501_ VAGYH 506_ SPYLH 511_ PGATG 516_ DPPRP 521_ LPRSF 526_ SPVLG 531_ PRPRE 536_ PSPVR 541_ YDNLS 546_ RTIMA 551_ SIQER 556_ KDREE 561_ RERLL 566_ RSQAD 571_ SLFGD 576_ SGVYD 581_ APSSY 586_ SLQQA 591_ SVLSE 596_ GPRGP 601_ ALRYG 606_ SRDDL 611_ VAGPG 616_ FGGAR 621_ NPALQ 626_ TSLSS 631_ LSSSV 636_ SRAPR 641_ TSSSS 646_ LQADQ 651_ ASSNA 656_ PGPRP 661_ SSGSH 666_ RSPAR 671_ QGLPS 676_ PPGTP 681_ HSPSY 686_ AGPKA 691_ VAFIH 696_ TDLPE 701_ PPPSL 706_ TVQRD 711_ HPQLK 716_ TPPSK 721_ LNGQS 726_ PGLAR 731_ LGPAT 736_ GPPGP 741_ SASPT 746_ RHTLV 751_ KKVSG 756_VGGTT
1: Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates and therefore functions in several unrelated biological processes (Probable). Through the palmitoylation of ABCA1 regulates the localization of the transporter to the plasma membrane and thereby regulates its function in cholesterol and phospholipid efflux (Probable). Could also pamitoylate the D(2) dopamine receptor DRD2 and regulate its stability and localization to the plasma membrane (Probable). Could also play a role in glutamatergic transmission (By similarity)
2: (Microbial infection) Able to palmitoylate SARS coronavirus-2/SARS-CoV-2 spike protein following its synthesis in the endoplasmic reticulum (ER). In the infected cell, promotes spike biogenesis by protecting it from premature ER degradation, increases half-life and controls the lipid organization of its immediate membrane environment. Once the virus has formed, spike palmitoylation controls fusion with the target cell