Protein inturned (Inturned planar cell polarity effector homolog) (PDZ domain-containing protein 6)
1_MASVA 6_ SCDSR 11_ PSSDE 16_ LPGDP 21_ SSQEE 26_ DEDYD 31_ FEDRV 36_ SDSGS 41_ YSSAS 46_ SDYDD 51_ LEPEW 56_ LDSVQ 61_ KNGEL 66_ FYLEL 71_ SEDEE 76_ ESLLP 81_ ETPTV 86_ NHVRF 91_ SENEI 96_ IIEDD 101_ YKERK 106_ KYEPK 111_ LKQFT 116_ KILRR 121_ KRLLP 126_ KRCNK 131_ KNSND 136_ NGPVS 141_ ILKHQ 146_ SNQKT 151_ GVIVQ 156_ QRYKD 161_ VNVYV 166_ NPKKL 171_ TVIKA 176_ KEQLK 181_ LLEVL 186_ VGIIH 191_ QTKWS 196_ WRRTG 201_ KQGDG 206_ ERLVV 211_ HGLLP 216_ GGSAM 221_ KSGQV 226_ LIGDV 231_ LVAVN 236_ DVDVT 241_ TENIE 246_ RVLSC 251_ IPGPM 256_ QVKLT 261_ FENAY 266_ DVKRE 271_ TSHPR 276_ QKKTQ 281_ SNTSD 286_ LVKLL 291_ WGEEV 296_ EGIQQ 301_ SGLNT 306_ PHIIM 311_ YLTLQ 316_ LDSET 321_ SKEEQ 326_ EILYH 331_ YPMSE 336_ ASQKL 341_ KSVRG 346_ IFLTL 351_ CDMLE 356_ NVTGT 361_ QVTSS 366_ SLLLN 371_ GKQIH 376_ VAYWK 381_ ESDKL 386_ LLIGL 391_ PAEEV 396_ PLPRL 401_ RNMIE 406_ NVIQT 411_ LKFMY 416_ GSLDS 421_ AFCQI 426_ ENVPR 431_ LDHFF 436_ NLFFQ 441_ RALQP 446_ AKLHS 451_ SASPS 456_ AQQYD 461_ ASSAV 466_ LLDNL 471_ PGVRW 476_ LTLPL 481_ EIKME 486_ LDMAL 491_ SDLEA 496_ ADFAE 501_ LSEDY 506_ YDMRR 511_ LYTIL 516_ GSSLF 521_ YKGYL 526_ ICSHL 531_ PKDDL 536_ IDIAV 541_ YCRHY 546_ CLLPL 551_ AAKQR 556_ IGQLI 561_ IWREV 566_ FPQHH 571_ LRPLA 576_ DSSTE 581_ VFPEP 586_ EGRYF 591_ LLVVG 596_ LKHYM 601_ LCVLL 606_ EAGGC 611_ ASKAI 616_ GSPGP 621_ DCVYV 626_ DQVKT 631_ TLHQL 636_ DGVDS 641_ RIDER 646_ LASSP 651_ VPCLS 656_ CADWF 661_ LTGSR 666_ EKTDS 671_ LTTSP 676_ ILSRL 681_ QGTSK 686_ VATSP 691_ TCRRT 696_ LFGDY 701_ SLKTR 706_ KPSPS 711_ CSSGG 716_ SDNGC 721_ EGGED 726_ DGFSP 731_ HTTPD 736_ AVRKQ 741_ RESQG 746_ SDGLE 751_ ESGTL 756_ LKVTK 761_ KKSTL 766_ PNPFH 771_ LGNLK 776_ KDLPE 781_ KELEI 786_ YNTVK 791_ LTSGP 796_ ENTLF 801_ HYVAL 806_ ETVQG 811_ IFITP 816_ TLEEV 821_ AQLSG 826_ SIHPQ 831_ LIKNF 836_ HQCCL 841_ SIRAV 846_ FQQTL 851_ VEEKK 856_ KGLNS 861_ GDHSD 866_ SAKSV 871_ SSLNP 876_ VKEHG 881_ VLFEC 886_ SPGNW 891_ TDQKK 896_ APPVM 901_ AYWVV 906_ GRLFL 911_ HPKPQ 916_ ELYVC 921_ FHDSV 926_ TEIAI 931_ EIAFK 936_LFFGL
1: Plays a key role in ciliogenesis and embryonic development. Regulator of cilia formation by controlling the organization of the apical actin cytoskeleton and the positioning of the basal bodies at the apical cell surface, which in turn is essential for the normal orientation of elongating ciliary microtubules. Plays a key role in definition of cell polarity via its role in ciliogenesis but not via conversion extension. Has an indirect effect on hedgehog signaling (By similarity). Proposed to function as core component of the CPLANE (ciliogenesis and planar polarity effectors) complex involved in the recruitment of peripheral IFT-A proteins to basal bodies (PubMed:27158779). Required for recruitment of CPLANE2 to the mother centriole (By similarity). Binds phosphatidylinositol 3-phosphate with highest affinity, followed by phosphatidylinositol 4-phosphate and phosphatidylinositol 5-phosphate (By similarity)