Kinase D-interacting substrate of 220 kDa (Ankyrin repeat-rich membrane-spanning protein)
1_MSVLI 6_ SQSVI 11_ NYVEE 16_ ENIPA 21_ LKALL 26_ EKCKD 31_ VDERN 36_ ECGQT 41_ PLMIA 46_ AEQGN 51_ LEIVK 56_ ELIKN 61_ GANCN 66_ LEDLD 71_ NWTAL 76_ ISASK 81_ EGHVH 86_ IVEEL 91_ LKCGV 96_ NLEHR 101_ DMGGW 106_ TALMW 111_ ACYKG 116_ RTDVV 121_ ELLLS 126_ HGANP 131_ SVTGL 136_ YSVYP 141_ IIWAA 146_ GRGHA 151_ DIVHL 156_ LLQNG 161_ AKVNC 166_ SDKYG 171_ TTPLV 176_ WAARK 181_ GHLEC 186_ VKHLL 191_ AMGAD 196_ VDQEG 201_ ANSMT 206_ ALIVA 211_ VKGGY 216_ TQSVK 221_ EILKR 226_ NPNVN 231_ LTDKD 236_ GNTAL 241_ MIASK 246_ EGHTE 251_ IVQDL 256_ LDAGT 261_ YVNIP 266_ DRSGD 271_ TVLIG 276_ AVRGG 281_ HVEIV 286_ RALLQ 291_ KYADI 296_ DIRGQ 301_ DNKTA 306_ LYWAV 311_ EKGNA 316_ TMVRD 321_ ILQCN 326_ PDTEI 331_ CTKDG 336_ ETPLI 341_ KATKM 346_ RNIEV 351_ VELLL 356_ DKGAK 361_ VSAVD 366_ KKGDT 371_ PLHIA 376_ IRGRS 381_ RKLAE 386_ LLLRN 391_ PKDGR 396_ LLYRP 401_ NKAGE 406_ TPYNI 411_ DCSHQ 416_ KSILT 421_ QIFGA 426_ RHLSP 431_ TETDG 436_ DMLGY 441_ DLYSS 446_ ALADI 451_ LSEPT 456_ MQPPI 461_ CVGLY 466_ AQWGS 471_ GKSFL 476_ LKKLE 481_ DEMKT 486_ FAGQQ 491_ IEPLF 496_ QFSWL 501_ IVFLT 506_ LLLCG 511_ GLGLL 516_ FAFTV 521_ HPNLG 526_ IAVSL 531_ SFLAL 536_ LYIFF 541_ IVIYF 546_ GGRRE 551_ GESWN 556_ WAWVL 561_ STRLA 566_ RHIGY 571_ LELLL 576_ KLMFV 581_ NPPEL 586_ PEQTT 591_ KALPV 596_ RFLFT 601_ DYNRL 606_ SSVGG 611_ ETSLA 616_ EMIAT 621_ LSDAC 626_ EREFG 631_ FLATR 636_ LFRVF 641_ KTEDT 646_ QGKKK 651_ WKKTC 656_ CLPSF 661_ VIFLF 666_ IIGCI 671_ ISGIT 676_ LLAIF 681_ RVDPK 686_ HLTVN 691_ AVLIS 696_ IASVV 701_ GLAFV 706_ LNCRT 711_ WWQVL 716_ DSLLN 721_ SQRKR 726_ LHNAA 731_ SKLHK 736_ LKSEG 741_ FMKVL 746_ KCEVE 751_ LMARM 756_ AKTID 761_ SFTQN 766_ QTRLV 771_ VIIDG 776_ LDACE 781_ QDKVL 786_ QMLDT 791_ VRVLF 796_ SKGPF 801_ IAIFA 806_ SDPHI 811_ IIKAI 816_ NQNLN 821_ SVLRD 826_ SNING 831_ HDYMR 836_ NIVHL 841_ PVFLN 846_ SRGLS 851_ NARKF 856_ LVTSA 861_ TNGDV 866_ PCSDT 871_ TGIQE 876_ DADRR 881_ VSQNS 886_ LGEMT 891_ KLGSK 896_ TALNR 901_ RDTYR 906_ RRQMQ 911_ RTITR 916_ QMSFD 921_ LTKLL 926_ VTEDW 931_ FSDIS 936_ PQTMR 941_ RLLNI 946_ VSVTG 951_ RLLRA 956_ NQISF 961_ NWDRL 966_ ASWIN 971_ LTEQW 976_ PYRTS 981_ WLILY 986_ LEETE 991_ GIPDQ 996_ MTLKT 1001_ IYERI 1006_ SKNIP 1011_ TTKDV 1016_ EPLLE 1021_ IDGDI 1026_ RNFEV 1031_ FLSSR 1036_ TPVLV 1041_ ARDVK 1046_ VFLPC 1051_ TVNLD 1056_ PKLRE 1061_ IIADV 1066_ RAARE 1071_ QISIG 1076_ GLAYP 1081_ PLPLH 1086_ EGPPR 1091_ APSGY 1096_ SQPPS 1101_ VCSST 1106_ SFNGP 1111_ FAGGV 1116_ VSPQP 1121_ HSSYY 1126_ SGMTG 1131_ PQHPF 1136_ YNRPF 1141_ FAPYL 1146_ YTPRY 1151_ YPGGS 1156_ QHLIS 1161_ RPSVK 1166_ TSLPR 1171_ DQNNG 1176_ LEVIK 1181_ EDAAE 1186_ GLSSP 1191_ TDSSR 1196_ GSGPA 1201_ PGPVV 1206_ LLNSL 1211_ NVDAV 1216_ CEKLK 1221_ QIEGL 1226_ DQSML 1231_ PQYCT 1236_ TIKKA 1241_ NINGR 1246_ VLAQC 1251_ NIDEL 1256_ KKEMN 1261_ MNFGD 1266_ WHLFR 1271_ STVLE 1276_ MRNAE 1281_ SHVVP 1286_ EDPRF 1291_ LSESS 1296_ SGPAP 1301_ HGEPA 1306_ RRASH 1311_ NELPH 1316_ TELSS 1321_ QTPYT 1326_ LNFSF 1331_ EELNT 1336_ LGLDE 1341_ GAPRH 1346_ SNLSW 1351_ QSQTR 1356_ RTPSL 1361_ SSLNS 1366_ QDSSI 1371_ EISKL 1376_ TDKVQ 1381_ AEYRD 1386_ AYREY 1391_ IAQMS 1396_ QLEGG 1401_ PGSTT 1406_ ISGRS 1411_ SPHST 1416_ YYMGQ 1421_ SSSGG 1426_ SIHSN 1431_ LEQEK 1436_ GKDSE 1441_ PKPDD 1446_ GRKSF 1451_ LMKRG 1456_ DVIDY 1461_ SSSGV 1466_ STNDA 1471_ SPLDP 1476_ ITEED 1481_ EKSDQ 1486_ SGSKL 1491_ LPGKK 1496_ SSERS 1501_ SLFQT 1506_ DLKLK 1511_ GSGLR 1516_ YQKLP 1521_ SDEDE 1526_ SGTEE 1531_ SDNTP 1536_ LLKDD 1541_ KDRKA 1546_ EGKVE 1551_ RVPKS 1556_ PEHSA 1561_ EPIRT 1566_ FIKAK 1571_ EYLSD 1576_ ALLDK 1581_ KDSSD 1586_ SGVRS 1591_ SESSP 1596_ NHSLH 1601_ NEVAD 1606_ DSQLE 1611_ KANLI 1616_ ELEDD 1621_ SHSGK 1626_ RGIPH 1631_ SLSGL 1636_ QDPII 1641_ ARMSI 1646_ CSEDK 1651_ KSPSE 1656_ CSLIA 1661_ SSPEE 1666_ NWPAC 1671_ QKAYN 1676_ LNRTP 1681_ STVTL 1686_ NNNSA 1691_ PANRA 1696_ NQNFD 1701_ EMEGI 1706_ RETSQ 1711_ VILRP 1716_ SSSPN 1721_ PTTIQ 1726_ NENLK 1731_ SMTHK 1736_ RSQRS 1741_ SYTRL 1746_ SKDPP 1751_ ELHAA 1756_ ASSES 1761_ TGFGE 1766_ERESI
1: Promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation. May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth. May play a role in neurotrophin- and ephrin-mediated neuronal outgrowth and in axon guidance during neural development and in neuronal regeneration (By similarity). Modulates stress-induced apoptosis of melanoma cells via regulation of the MEK/ERK signaling pathway