Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 (130 kDa phosphatidylinositol 4,5-bisphosphate-dependent ARF1 GTPase-activating protein) (ADP-ribosylation factor-directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (DEF-1) (Differentiation-enhancing factor 1) (PIP2-dependent ARF1 GAP)
1_MRSSA 6_ SRLSS 11_ FSSRD 16_ SLWNR 21_ MPDQI 26_ SVSEF 31_ IAETT 36_ EDYNS 41_ PTTSS 46_ FTTRL 51_ HNCRN 56_ TVTLL 61_ EEALD 66_ QDRTA 71_ LQKVK 76_ KSVKA 81_ IYNSG 86_ QDHVQ 91_ NEENY 96_ AQVLD 101_ KFGSN 106_ FLSRD 111_ NPDLG 116_ TAFVK 121_ FSTLT 126_ KELST 131_ LLKNL 136_ LQGLS 141_ HNVIF 146_ TLDSL 151_ LKGDL 156_ KGVKG 161_ DLKKP 166_ FDKAW 171_ KDYET 176_ KFTKI 181_ EKEKR 186_ EHAKQ 191_ HGMIR 196_ TEITG 201_ AEIAE 206_ EMEKE 211_ RRLFQ 216_ LQMCE 221_ YLIKV 226_ NEIKT 231_ KKGVD 236_ LLQNL 241_ IKYYH 246_ AQCNF 251_ FQDGL 256_ KTADK 261_ LKQYI 266_ EKLAA 271_ DLYNI 276_ KQTQD 281_ EEKKQ 286_ LTALR 291_ DLIKS 296_ SLQLD 301_ QKEDS 306_ QSRQG 311_ GYSMH 316_ QLQGN 321_ KEYGS 326_ EKKGY 331_ LLKKS 336_ DGIRK 341_ VWQRR 346_ KCSVK 351_ NGILT 356_ ISHAT 361_ SNRQP 366_ AKLNL 371_ LTCQV 376_ KPNAE 381_ DKKSF 386_ DLISH 391_ NRTYH 396_ FQAED 401_ EQDYV 406_ AWISV 411_ LTNSK 416_ EEALT 421_ MAFRG 426_ EQSAG 431_ ENSLE 436_ DLTKA 441_ IIEDV 446_ QRLPG 451_ NDICC 456_ DCGSS 461_ EPTWL 466_ STNLG 471_ ILTCI 476_ ECSGI 481_ HREMG 486_ VHISR 491_ IQSLE 496_ LDKLG 501_ TSELL 506_ LAKNV 511_ GNNSF 516_ NDIME 521_ ANLPS 526_ PSPKP 531_ TPSSD 536_ MTVRK 541_ EYITA 546_ KYVDH 551_ RFSRK 556_ TCSTS 561_ SAKLN 566_ ELLEA 571_ IKSRD 576_ LLALI 581_ QVYAE 586_ GVELM 591_ EPLLE 596_ PGQEL 601_ GETAL 606_ HLAVR 611_ TADQT 616_ SLHLV 621_ DFLVQ 626_ NCGNL 631_ DKQTA 636_ LGNTV 641_ LHYCS 646_ MYSKP 651_ ECLKL 656_ LLRSK 661_ PTVDI 666_ VNQAG 671_ ETALD 676_ IAKRL 681_ KATQC 686_ EDLLS 691_ QAKSG 696_ KFNPH 701_ VHVEY 706_ EWNLR 711_ QEEID 716_ ESDDD 721_ LDDKP 726_ SPIKK 731_ ERSPR 736_ PQSFC 741_ HSSSI 746_ SPQDK 751_ LALPG 756_ FSTPR 761_ DKQRL 766_ SYGAF 771_ TNQIF 776_ VSTST 781_ DSPTS 786_ PTTEA 791_ PPLPP 796_ RNAGK 801_ GPTGP 806_ PSTLP 811_ LSTQT 816_ SSGSS 821_ TLSKK 826_ RPPPP 831_ PPGHK 836_ RTLSD 841_ PPSPL 846_ PHGPP 851_ NKGAV 856_ PWGND 861_ GGPSS 866_ SSKTT 871_ NKFEG 876_ LSQQS 881_ STSSA 886_ KTALG 891_ PRVLP 896_ KLPQK 901_ VALRK 906_ TDHLS 911_ LDKAT 916_ IPPEI 921_ FQKSS 926_ QLAEL 931_ PQKPP 936_ PGDLP 941_ PKPTE 946_ LAPKP 951_ QIGDL 956_ PPKPG 961_ ELPPK 966_ PQLGD 971_ LPPKP 976_ QLSDL 981_ PPKPQ 986_ MKDLP 991_ PKPQL 996_ GDLLA 1001_ KSQTG 1006_ DVSPK 1011_ AQQPS 1016_ EVTLK 1021_ SHPLD 1026_ LSPNV 1031_ QSRDA 1036_ IQKQA 1041_ SEDSN 1046_ DLTPT 1051_ LPETP 1056_ VPLPR 1061_ KINTG 1066_ KNKVR 1071_ RVKTI 1076_ YDCQA 1081_ DNDDE 1086_ LTFIE 1091_ GEVII 1096_ VTGEE 1101_ DQEWW 1106_ IGHIE 1111_ GQPER 1116_ KGVFP 1121_VSFVH
1: Possesses phosphatidylinositol 4,5-bisphosphate-dependent GTPase-activating protein activity for ARF1 (ADP ribosylation factor 1) and ARF5 and a lesser activity towards ARF6. May coordinate membrane trafficking with cell growth or actin cytoskeleton remodeling by binding to both SRC and PIP2. May function as a signal transduction protein involved in the differentiation of fibroblasts into adipocytes and possibly other cell types. Part of the ciliary targeting complex containing Rab11, ASAP1, Rabin8/RAB3IP, RAB11FIP3 and ARF4, which direct preciliary vesicle trafficking to mother centriole and ciliogenesis initiation (PubMed:25673879)