Glutamate receptor ionotropic, delta-1 (GluD1) (GluR delta-1 subunit)
1_MEALT 6_ LWLLP 11_ WICQC 16_ VSVRA 21_ DSIIH 26_ IGAIF 31_ EENAA 36_ KDDRV 41_ FQLAV 46_ SDLSL 51_ NDDIL 56_ QSEKI 61_ TYSIK 66_ VIEAN 71_ NPFQA 76_ VQEAC 81_ DLMTQ 86_ GILAL 91_ VTSTG 96_ CASAN 101_ ALQSL 106_ TDAMH 111_ IPHLF 116_ VQRNP 121_ GGSPR 126_ TACHL 131_ NPSPD 136_ GEAYT 141_ LASRP 146_ PVRLN 151_ DVMLR 156_ LVTEL 161_ RWQKF 166_ VMFYD 171_ SEYDI 176_ RGLQS 181_ FLDQA 186_ SRLGL 191_ DVSLQ 196_ KVDKN 201_ ISHVF 206_ TSLFT 211_ TMKTE 216_ ELNRY 221_ RDTLR 226_ RAILL 231_ LSPQG 236_ AHSFI 241_ NEAVE 246_ TNLAS 251_ KDSHW 256_ VFVNE 261_ EISDP 266_ EILDL 271_ VHSAL 276_ GRMTV 281_ VRQIF 286_ PSAKD 291_ NQKCT 296_ RNNHR 301_ ISSLL 306_ CDPQE 311_ GYLQM 316_ LQISN 321_ LYLYD 326_ SVLML 331_ ANAFH 336_ RKLED 341_ RKWHS 346_ MASLN 351_ CIRKS 356_ TKPWN 361_ GGRSM 366_ LDTIK 371_ KGHIT 376_ GLTGV 381_ MEFRE 386_ DSSNP 391_ YVQFE 396_ ILGTT 401_ YSETF 406_ GKDMR 411_ KLATW 416_ DSEKG 421_ LNGSL 426_ QERPM 431_ GSRLQ 436_ GLTLK 441_ VVTVL 446_ EEPFV 451_ MVAEN 456_ ILGQP 461_ KRYKG 466_ FSIDV 471_ LDALA 476_ KALGF 481_ KYEIY 486_ QAPDG 491_ RYGHQ 496_ LHNTS 501_ WNGMI 506_ GELIS 511_ KRADL 516_ AISAI 521_ TITPE 526_ RESVV 531_ DFSKR 536_ YMDYS 541_ VGILI 546_ KKPEE 551_ KISIF 556_ SLFAP 561_ FDFAV 566_ WACIA 571_ AAIPV 576_ VGVLI 581_ FVLNR 586_ IQAVR 591_ AQSAA 596_ QPRPS 601_ ASATL 606_ HSAIW 611_ IVYGA 616_ FVQQG 621_ GESSV 626_ NSMAM 631_ RIVMG 636_ SWWLF 641_ TLIVC 646_ SSYTA 651_ NLAAF 656_ LTVSR 661_ MDNPI 666_ RTFQD 671_ LSKQV 676_ EMSYG 681_ TVRDS 686_ AVYEY 691_ FRAKG 696_ TNPLE 701_ QDSTF 706_ AELWR 711_ TISKN 716_ GGADN 721_ CVSSP 726_ SEGIR 731_ KAKKG 736_ NYAFL 741_ WDVAV 746_ VEYAA 751_ LTDDD 756_ CSVTV 761_ IGNSI 766_ SSKGY 771_ GIALQ 776_ HGSPY 781_ RDLFS 786_ QRILE 791_ LQDTG 796_ DLDVL 801_ KQKWW 806_ PHMGR 811_ CDLTS 816_ HASAQ 821_ ADGKS 826_ LKLHS 831_ FAGVF 836_ CILAI 841_ GLLLA 846_ CLVAA 851_ LELWW 856_ NSNRC 861_ HQETP 866_ KEDKE 871_ VNLEQ 876_ VHRRM 881_ NSLMD 886_ EDIAH 891_ KQISP 896_ ASIEL 901_ SALEM 906_ GGLAP 911_ TQTLE 916_ PTREY 921_ QNTQL 926_ SVSTF 931_ LPEQS 936_ SHGTS 941_ RTLSS 946_ GPSSN 951_ LPLPL 956_ SSSAT 961_ MPSMQ 966_ CKHRS 971_ PNGGL 976_ FRQSP 981_ VKTPI 986_ PMSFQ 991_ PVPGG 996_ VLPEA 1001_LDTSH
1: Member of the ionotropic glutamate receptor family, which plays a crucial role in synaptic organization and signal transduction in the central nervous system. Although it shares structural features with ionotropic glutamate receptors, does not bind glutamate as a primary ligand (PubMed:38060673). Instead, forms trans-synaptic adhesion complexes with presynaptic neurexins and cerebellins, regulating NMDA and AMPA receptor activity and influencing synaptic plasticity through signal transduction (By similarity). In the presence of neurexins and cerebellins, forms cation-selective channels that are proposed to be gated by glycine and D-serine (By similarity). However, recent research disputes this ligand-gated cation channel activity (PubMed:39052831). Cation-selective ion channel can be triggered by GRM1 in dopaminergic neurons (By similarity). Also acts as a receptor for GABA, modulating inhibitory synaptic plasticity through non-ionotropic mechanisms (PubMed:38060673)