Vang-like protein 2 (Loop-tail protein 1 homolog) (Strabismus 1) (Van Gogh-like protein 2)
1_MDTES 6_ QYSGY 11_ SYKSG 16_ HSRSS 21_ RKHRD 26_ RRDRH 31_ RSKSR 36_ DGGRG 41_ DKSVT 46_ IQAPG 51_ EPLLD 56_ NESTR 61_ GDERD 66_ DNWGE 71_ TTTVV 76_ TGTSE 81_ HSISH 86_ DDLTR 91_ IAKDM 96_ EDSVP 101_ LDCSR 106_ HLGVA 111_ AGATL 116_ ALLSF 121_ LTPLA 126_ FLLLP 131_ PLLWR 136_ EELEP 141_ CGTAC 146_ EGLFI 151_ SVAFK 156_ LLILL 161_ LGSWA 166_ LFFRR 171_ PKASL 176_ PRVFV 181_ LRALL 186_ MVLVF 191_ LLVVS 196_ YWLFY 201_ GVRIL 206_ DARER 211_ SYQGV 216_ VQFAV 221_ SLVDA 226_ LLFVH 231_ YLAVV 236_ LLELR 241_ QLQPQ 246_ FTLKV 251_ VRSTD 256_ GASRF 261_ YNVGH 266_ LSIQR 271_ VAVWI 276_ LEKYY 281_ HDFPV 286_ YNPAL 291_ LNLPK 296_ SVLAK 301_ KVSGF 306_ KVYSL 311_ GEENS 316_ TNNST 321_ GQSRA 326_ VIAAA 331_ ARRRD 336_ NSHNE 341_ YYYEE 346_ AEHER 351_ RVRKR 356_ RARLV 361_ VAVEE 366_ AFTHI 371_ KRLQE 376_ EEQKN 381_ PREVM 386_ DPREA 391_ AQAIF 396_ ASMAR 401_ AMQKY 406_ LRTTK 411_ QQPYH 416_ TMESI 421_ LQHLE 426_ FCITH 431_ DMTPK 436_ AFLER 441_ YLAAG 446_ PTIQY 451_ HKERW 456_ LAKQW 461_ TLVSE 466_ EPVTN 471_ GLKDG 476_ IVFLL 481_ KRQDF 486_ SLVVS 491_ TKKVP 496_ FFKLS 501_ EEFVD 506_ PKSHK 511_ FVMRL 516_QSETS
1: Involved in the control of early morphogenesis and patterning of both axial midline structures and the development of neural plate. Plays a role in the regulation of planar cell polarity, particularly in the orientation of stereociliary bundles in the cochlea. Required for polarization and movement of myocardializing cells in the outflow tract and seems to act via RHOA signaling to regulate this process. Required for cell surface localization of FZD3 and FZD6 in the inner ear (By similarity)