CCR4-NOT transcription complex subunit 6 (EC 3.1.13.4) (CCR4 carbon catabolite repression 4-like) (Carbon catabolite repressor protein 4 homolog) (Cytoplasmic deadenylase)
1_MPKEK 6_ YEPPD 11_ PRRMY 16_ TIMSS 21_ EEAAN 26_ GKKSH 31_ WAELE 36_ ISGKV 41_ RSLSA 46_ SLWSL 51_ THLTA 56_ LHLSD 61_ NSLSR 66_ IPSDI 71_ AKLHN 76_ LVYLD 81_ LSSNK 86_ IRSLP 91_ AELGN 96_ MVSLR 101_ ELHLN 106_ NNLLR 111_ VLPFE 116_ LGKLF 121_ QLQTL 126_ GLKGN 131_ PLTQD 136_ ILNLY 141_ QEPDG 146_ TRRLL 151_ NYLLD 156_ NLSGT 161_ AKRIT 166_ TEQPP 171_ PRSWI 176_ MLQEP 181_ DRTRP 186_ TALFS 191_ VMCYN 196_ VLCDK 201_ YATRQ 206_ LYGYC 211_ PSWAL 216_ NWDYR 221_ KKAII 226_ QEILS 231_ CNADI 236_ VSLQE 241_ VETEQ 246_ YYSFF 251_ LVELK 256_ ERGYN 261_ GFFSP 266_ KSRAR 271_ TMSEQ 276_ ERKHV 281_ DGCAI 286_ FFKTE 291_ KFTLV 296_ QKHTV 301_ EFNQL 306_ AMANS 311_ EGSEA 316_ MLNRV 321_ MTKDN 326_ IGVAV 331_ LLELR 336_ KESIE 341_ MPSGK 346_ PHLGT 351_ EKQLI 356_ LVANA 361_ HMHWD 366_ PEYSD 371_ VKLVQ 376_ TMMFL 381_ SEVKN 386_ IIDKA 391_ SRNLK 396_ SSVLG 401_ EFGTI 406_ PLVLC 411_ ADLNS 416_ LPDSG 421_ VVEYL 426_ STGGV 431_ ETNHK 436_ DFKEL 441_ RYNES 446_ LTNFS 451_ CHGKN 456_ GTTNG 461_ RITHG 466_ FKLQS 471_ AYESG 476_ LMPYT 481_ NYTFD 486_ FKGII 491_ DYIFY 496_ SKPQL 501_ NTLGI 506_ LGPLD 511_ HHWLV 516_ ENNIS 521_ GCPHP 526_ LIPSD 531_ HFSLF 536_ AQLEL 541_ LLPFL 546_ PQVNG 551_IHLPG
1: Poly(A) nuclease with 3'-5' RNase activity. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Involved in mRNA decay mediated by the major-protein-coding determinant of instability (mCRD) of the FOS gene in the cytoplasm. In the presence of ZNF335, enhances ligand-dependent transcriptional activity of nuclear hormone receptors, including RARA. The increase of ligand-dependent ESR1-mediated transcription is much smaller, if any. Mediates cell proliferation and cell survival and prevents cellular senescence