Two pore channel protein 1 (Two pore calcium channel protein 1) (Voltage-dependent calcium channel protein TPC1)
1_MAVSL 6_ DDDVP 11_ LILTL 16_ DEGGS 21_ APLAP 26_ SNGLG 31_ QEELP 36_ SKNGG 41_ SYAIH 46_ DSQAP 51_ SLSSG 56_ GESSP 61_ SSPAH 66_ NWEMN 71_ YQEAA 76_ IYLQE 81_ GENND 86_ KFFTH 91_ PKDAK 96_ ALAAY 101_ LFAHN 106_ HLFYL 111_ MELAT 116_ ALLLL 121_ LLSLC 126_ EAPAV 131_ PALRL 136_ GIYVH 141_ ATLEL 146_ FALMV 151_ VVFEL 156_ CMKLR 161_ WLGLH 166_ TFIRH 171_ KRTMV 176_ KTSVL 181_ VVQFV 186_ EAIVV 191_ LVRQM 196_ SHVRV 201_ TRALR 206_ CIFLV 211_ DCRYC 216_ GGVRR 221_ NLRQI 226_ FQSLP 231_ PFMDI 236_ LLLLL 241_ FFMII 246_ FAILG 251_ FYLFS 256_ PNPSD 261_ PYFST 266_ LENSI 271_ VSLFV 276_ LLTTA 281_ NFPDV 286_ MMPSY 291_ SRNPW 296_ SCVFF 301_ IVYLS 306_ IELYF 311_ IMNLL 316_ LAVVF 321_ DTFND 326_ IEKRK 331_ FKSLL 336_ LHKRT 341_ AIQHA 346_ YRLLI 351_ SQRRP 356_ AGISY 361_ RQFEG 366_ LMRFY 371_ KPRMS 376_ ARERY 381_ LTFKA 386_ LNQNN 391_ TPLLS 396_ LKDFY 401_ DIYEV 406_ AALKW 411_ KAKKN 416_ REHWF 421_ DELPR 426_ TALLI 431_ FKGIN 436_ ILVKS 441_ KAFQY 446_ FMYLV 451_ VAVNG 456_ VWILV 461_ ETFML 466_ KGGNF 471_ FSKHV 476_ PWSYL 481_ VFLTI 486_ YGVEL 491_ FLKVA 496_ GLGPV 501_ EYLSS 506_ GWNLF 511_ DFSVT 516_ VFAFL 521_ GLLAL 526_ ALNME 531_ PFYFI 536_ VVLRP 541_ LQLLR 546_ LFKLK 551_ ERYRN 556_ VLDTM 561_ FELLP 566_ RMASL 571_ GLTLL 576_ IFYYS 581_ FAIVG 586_ MEFFC 591_ GIVFP 596_ NCCNT 601_ STVAD 606_ AYRWR 611_ NHTVG 616_ NRTVV 621_ EEGYY 626_ YLNNF 631_ DNILN 636_ SFVTL 641_ FELTV 646_ VNNWY 651_ IIMEG 656_ VTSQT 661_ SHWSR 666_ LYFMT 671_ FYIVT 676_ MVVMT 681_ IIVAF 686_ ILEAF 691_ VFRMN 696_ YSRKN 701_ QDSEV 706_ DGGIT 711_ LEKEI 716_ SKEEL 721_ VAVLE 726_ LYREA 731_ RGASS 736_ DVTRL 741_ LETLS 746_ QMERY 751_ QQHSM 756_ VFLGR 761_ RSRTK 766_ SDLSL 771_ KMYQE 776_ EIQEW 781_ YEEHA 786_ REQEQ 791_ QRQLS 796_ SSAAP 801_ AAQQP 806_ PGSRQ 811_RSQTV
1: Intracellular channel initially characterized as a non-selective Ca(2+)-permeable channel activated by NAADP (nicotinic acid adenine dinucleotide phosphate), it is also a voltage-gated highly-selective Na(+) channel activated directly by PI(3,5)P2 (phosphatidylinositol 3,5-bisphosphate) that senses pH changes and confers electrical excitability to organelles (PubMed:19620632, PubMed:23063126, PubMed:23394946, PubMed:24776928). Localizes to the early and recycling endosomes membranes where it plays a role in the uptake and processing of proteins and regulates organellar membrane excitability, membrane trafficking and pH homeostasis (Probable) (PubMed:23394946). Ion selectivity is not fixed but rather agonist-dependent and under defined ionic conditions, can be readily activated by both NAADP and PI(3,5)P2 (Probable). Required for mTOR-dependent nutrient sensing (Probable) (PubMed:23394946)
2: (Microbial infection) During Ebola virus (EBOV) infection, controls the movement of endosomes containing virus particles and is required by EBOV to escape from the endosomal network into the cell cytoplasm