Pre-mRNA-splicing factor ISY1 homolog
1_MARNA 6_ EKAMT 11_ ALARF 16_ RQAQL 21_ EEGKV 26_ KERRP 31_ FLASE 36_ CTELP 41_ KAEKW 46_ RRQII 51_ GEISK 56_ KVAQI 61_ QNAGL 66_ GEFRI 71_ RDLND 76_ EINKL 81_ LREKG 86_ HWEVR 91_ IKELG 96_ GPDYG 101_ KVGPK 106_ MLDHE 111_ GKEVP 116_ GNRGY 121_ KYFGA 126_ AKDLP 131_ GVREL 136_ FEKEP 141_ LPPPR 146_ KTRAE 151_ LMKAI 156_ DFEYY 161_ GYLDE 166_ DDGVI 171_ VPLEQ 176_ EYEKK 181_ LRAEL 186_ VEKWK 191_ AEREA 196_ RLARG 201_ EKEEE 206_ EEEEE 211_ EINIY 216_ AVTEE 221_ ESDEE 226_ GSQEK 231_ GGDDS 236_ QQKFI 241_ AHVPV 246_ PSQQE 251_ IEEAL 256_ VRRKK 261_ MELLQ 266_ KYASE 271_ TLQAQ 276_SEEAR
1: Component of the spliceosome C complex required for the selective processing of microRNAs during embryonic stem cell differentiation (By similarity). Required for the biogenesis of all miRNAs from the pri-miR-17-92 primary transcript except miR-92a (By similarity). Only required for the biogenesis of miR-290 and miR-96 from the pri-miR-290-295 and pri-miR-96-183 primary transcripts, respectively (By similarity). Required during the transition of embryonic stem cells (ESCs) from the naive to primed state (By similarity). By enhancing miRNA biogenesis, promotes exit of ESCs from the naive state to an intermediate state of poised pluripotency, which precedes transition to the primed state (By similarity). Involved in pre-mRNA splicing as component of the spliceosome