Potassium voltage-gated channel subfamily S member 2 (Delayed-rectifier K(+) channel alpha subunit 2) (Voltage-gated potassium channel subunit Kv9.2)
1_MTGQS 6_ LWDVS 11_ EANVE 16_ DGEIR 21_ INVGG 26_ FKRRL 31_ RSHTL 36_ LRFPE 41_ TRLGR 46_ LLLCH 51_ SREAI 56_ LELCD 61_ DYDDV 66_ QREFY 71_ FDRNP 76_ ELFPY 81_ VLHFY 86_ HTGKL 91_ HVMAE 96_ LCVFS 101_ FSQEI 106_ EYWGI 111_ NEFFI 116_ DSCCS 121_ YSYHG 126_ RKVEP 131_ EQEKW 136_ DEQSD 141_ QESTT 146_ SSFDE 151_ ILAFY 156_ NDASK 161_ FDGQP 166_ LGNFR 171_ RQLWL 176_ ALDNP 181_ GYSVL 186_ SRVFS 191_ ILSIL 196_ VVMGS 201_ IITMC 206_ LNSLP 211_ DFQIP 216_ DSQGN 221_ PGEDP 226_ RFEIV 231_ EHFGI 236_ AWFTF 241_ ELVAR 246_ FAVAP 251_ DFLKF 256_ FKNAL 261_ NLIDL 266_ MSIVP 271_ FYITL 276_ VVNLV 281_ VESTP 286_ TLANL 291_ GRVAQ 296_ VLRLM 301_ RIFRI 306_ LKLAR 311_ HSTGL 316_ RSLGA 321_ TLKYS 326_ YKEVG 331_ LLLLY 336_ LSVGI 341_ SIFSV 346_ VAYTI 351_ EKEEN 356_ EGLAT 361_ IPACW 366_ WWATV 371_ SMTTV 376_ GYGDV 381_ VPGTT 386_ AGKLT 391_ ASACI 396_ LAGIL 401_ VVVLP 406_ ITLIF 411_ NKFSH 416_ FYRRQ 421_ KQLES 426_ AMRSC 431_ DFGDG 436_ MKEVP 441_ SVNLR 446_ DYYAH 451_ KVKSL 456_ MASLT 461_ NMSRS 466_ SPSEL 471_SLNDS
1: Potassium channel regulatory subunit that modulate the delayed rectifier voltage-gated potassium channel activity of KCNB1 and KCNB2 by altering their kinetics, expression levels, and shifting the half-inactivation potential to more polarized values. While it does not form functional channels on its own, it can form functional heterotetrameric channels with KCNB1 and KCNB2. Each regulatory subunit has unique regulatory properties that can lead to extensive inhibition, significant changes in kinetics, and/or substantial shifts in the voltage dependencies of the inactivation process