E3 ubiquitin-protein ligase ZNRF3 (EC 2.3.2.27) (RING finger protein 203) (RING-type E3 ubiquitin transferase ZNRF3) (Zinc/RING finger protein 3)
1_MRPRS 6_ GGRPG 11_ ATGRR 16_ RRRLR 21_ RRPRG 26_ LRCSR 31_ LPPPP 36_ PLPLL 41_ LGLLL 46_ AAAGP 51_ GAARA 56_ KETAF 61_ VEVVL 66_ FESSP 71_ SGDYT 76_ TYTTG 81_ LTGRF 86_ SRAGA 91_ TLSAE 96_ GEIVQ 101_ MHPLG 106_ LCNNN 111_ DEEDL 116_ YEYGW 121_ VGVVK 126_ LEQPE 131_ LDPKP 136_ CLTVL 141_ GKAKR 146_ AVQRG 151_ ATAVI 156_ FDVSE 161_ NPEAI 166_ DQLNQ 171_ GSEDP 176_ LKRPV 181_ VYVKG 186_ ADAIK 191_ LMNIV 196_ NKQKV 201_ ARARI 206_ QHRPP 211_ RQPTE 216_ YFDMG 221_ IFLAF 226_ FVVVS 231_ LVCLI 236_ LLVKI 241_ KLKQR 246_ RSQNS 251_ MNRLA 256_ VQALE 261_ KMETR 266_ KFNSK 271_ SKGRR 276_ EGSCG 281_ ALDTL 286_ SSSST 291_ SDCAI 296_ CLEKY 301_ IDGEE 306_ LRVIP 311_ CTHRF 316_ HRKCV 321_ DPWLL 326_ QHHTC 331_ PHCRH 336_ NIIEQ 341_ KGNPS 346_ AVCVE 351_ TSNLS 356_ RGRQQ 361_ RVTLP 366_ VHYPG 371_ RVHRT 376_ NAIPA 381_ YPTRT 386_ SMDSH 391_ GNPVT 396_ LLTMD 401_ RHGEQ 406_ SLYSP 411_ QTPAY 416_ IRSYP 421_ PLHLD 426_ HSLAA 431_ HRCGL 436_ EHRAY 441_ SPAHP 446_ FRRPK 451_ LSGRS 456_ FSKAA 461_ CFSQY 466_ ETMYQ 471_ HYYFQ 476_ GLSYP 481_ EQEGQ 486_ SPPSL 491_ APRGP 496_ ARAFP 501_ PSGSG 506_ SLLFP 511_ TVVHV 516_ APPSH 521_ LESGS 526_ TSSFS 531_ CYHGH 536_ RSVCS 541_ GYLAD 546_ CPGSD 551_ SSSSS 556_ SSGQC 561_ HCSSS 566_ DSVVD 571_ CTEVS 576_ NQGVY 581_ GSCST 586_ FRSSL 591_ SSDYD 596_ PFIYR 601_ SRSPC 606_ RASEA 611_ GGSGS 616_ SGRGP 621_ ALCFE 626_ GSPPP 631_ EELPA 636_ VHSHG 641_ AGRGE 646_ PWPGP 651_ ASPSG 656_ DQVST 661_ CSLEM 666_ NYSSN 671_ SSLEH 676_ RGPNS 681_ STSEV 686_ GLEAS 691_ PGAAP 696_ DLRRT 701_ WKGGH 706_ ELPSC 711_ ACCCE 716_ PQPSP 721_ AGPSA 726_ GAAGS 731_ STLFL 736_ GPHLY 741_ EGSGP 746_ AGGEP 751_ QSGSS 756_ QGLYG 761_ LHPDH 766_ LPRTD 771_ GVKYE 776_ GLPCC 781_ FYEEK 786_ QVARG 791_ GGGGS 796_ GCYTE 801_ DYSVS 806_ VQYTL 811_ TEEPP 816_ PGCYP 821_ GARDL 826_ SQRIP 831_ IIPED 836_ VDCDL 841_ GLPSD 846_ CQGTH 851_ SLGSW 856_ GGTRG 861_ PDTPR 866_ PHRGL 871_ GATRE 876_ EERAL 881_ CCQAR 886_ ALLRP 891_ GCPPE 896_ EAGAV 901_ RANFP 906_ SALQD 911_ TQESS 916_ TTATE 921_ AAGPR 926_ SHSAD 931_SSSPG
1: E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components Frizzled and LRP6. Acts on both canonical and non-canonical Wnt signaling pathway. Acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway, thereby restricting the size of the intestinal stem cell zone (PubMed:22575959). Along with RSPO2 and RNF43, constitutes a master switch that governs limb specification (By similarity)