E3 ubiquitin-protein ligase HECTD1 (EC 2.3.2.26) (E3 ligase for inhibin receptor) (EULIR) (HECT domain-containing protein 1) (HECT-type E3 ubiquitin transferase HECTD1)
1_MADVD 6_ PDTLL 11_ EWLQM 16_ GQGDE 21_ RDMQL 26_ IALEQ 31_ LCMLL 36_ LMSDN 41_ VDRCF 46_ ETCPP 51_ RTFLP 56_ ALCKI 61_ FLDES 66_ APDNV 71_ LEVTA 76_ RAITY 81_ YLDVS 86_ AECTR 91_ RIVGV 96_ DGAIK 101_ ALCNR 106_ LVVVE 111_ LNNRT 116_ SRDLA 121_ EQCVK 126_ VLELI 131_ CTRES 136_ GAVFE 141_ AGGLN 146_ CVLTF 151_ IRDSG 156_ HLVHK 161_ DTLHS 166_ AMAVV 171_ SRLCG 176_ KMEPQ 181_ DSSLE 186_ ICVES 191_ LSSLL 196_ KHEDH 201_ QVSDG 206_ ALRCF 211_ ASLAD 216_ RFTRR 221_ GVDPA 226_ PLAKH 231_ GLTEE 236_ LLSRM 241_ AAAGG 246_ TVSGP 251_ SSACK 256_ PGRST 261_ TGAPS 266_ TTADS 271_ KLSNQ 276_ VSTIV 281_ SLLST 286_ LCRGS 291_ PVVTH 296_ DLLRS 301_ ELPDS 306_ IESAL 311_ QGDER 316_ CVLDT 321_ MRLVD 326_ LLLVL 331_ LFEGR 336_ KALPK 341_ SSAGS 346_ TGRIP 351_ GLRRL 356_ DSSGE 361_ RSHRQ 366_ LIDCI 371_ RSKDT 376_ DALID 381_ AIDTG 386_ AFEVN 391_ FMDDV 396_ GQTLL 401_ NWASA 406_ FGTQE 411_ MVEFL 416_ CERGA 421_ DVNRG 426_ QRSSS 431_ LHYAA 436_ CFGRP 441_ QVAKT 446_ LLRHG 451_ ANPDL 456_ RDEDG 461_ KTPLD 466_ KARER 471_ GHSEV 476_ VAILQ 481_ SPGDW 486_ MCPVN 491_ KGDDK 496_ KKKDT 501_ NKDEE 506_ ECNEP 511_ KGDPE 516_ MAPIY 521_ LKRLL 526_ PVFAQ 531_ TFQQT 536_ MLPSI 541_ RKASL 546_ ALIRK 551_ MIHFC 556_ SEALL 561_ KEVCD 566_ SDVGH 571_ NLPTI 576_ LVEIT 581_ ATVLD 586_ QEDDD 591_ DGHLL 596_ ALQII 601_ RDLVD 606_ KGGDI 611_ FLDQL 616_ ARLGV 621_ ISKVS 626_ TLAGP 631_ SSDDE 636_ NEEES 641_ KPEKE 646_ DEPQE 651_ DAKEL 656_ QQGKP 661_ YHWRD 666_ WSIIR 671_ GRDCL 676_ YIWSD 681_ AAALE 686_ LSNGS 691_ NGWFR 696_ FILDG 701_ KLATM 706_ YSSGS 711_ PEGGS 716_ DSSES 721_ RSEFL 726_ EKLQR 731_ ARGQV 736_ KPSTS 741_ SQPIL 746_ SAPGP 751_ TKLTV 756_ GNWSL 761_ TCLKE 766_ GEIAI 771_ HNSDG 776_ QQATI 781_ LKEDL 786_ PGFVF 791_ ESNRG 796_ TKHSF 801_ TAETS 806_ LGSEF 811_ VTGWT 816_ GKRGR 821_ KLKSK 826_ LEKTK 831_ QKVRT 836_ MARDL 841_ YDDHF 846_ KAVES 851_ MPRGV 856_ VVTLR 861_ NIATQ 866_ LESSW 871_ ELHTN 876_ RQCIE 881_ SENTW 886_ RDLMK 891_ TALEN 896_ LIVLL 901_ KDENT 906_ ISPYE 911_ MCSSG 916_ LVQAL 921_ LTVLN 926_ NSMDL 931_ DMKQD 936_ CSQLV 941_ ERINV 946_ FKTAF 951_ SENED 956_ DESRP 961_ AVALI 966_ RKLIA 971_ VLESI 976_ ERLPL 981_ HLYDT 986_ PGSTY 991_ NLQIL 996_ TRRLR 1001_ FRLER 1006_ APGET 1011_ ALIDR 1016_ TGRML 1021_ KMEPL 1026_ ATVES 1031_ LEQYL 1036_ LKMVA 1041_ KQWYD 1046_ FDRSS 1051_ FVFVR 1056_ KLREG 1061_ QNFIF 1066_ RHQHD 1071_ FDENG 1076_ IIYWI 1081_ GTNAK 1086_ TAYEW 1091_ VNPAA 1096_ YGLVV 1101_ VTSSE 1106_ GRNLP 1111_ YGRLE 1116_ DILSR 1121_ DNSAL 1126_ NCHSN 1131_ DDKNA 1136_ WFAID 1141_ LGLWV 1146_ IPSAY 1151_ TLRHA 1156_ RGYGR 1161_ SALRN 1166_ WVFQV 1171_ SKDGQ 1176_ NWTSL 1181_ YTHVD 1186_ DCSLN 1191_ EPGST 1196_ ATWPL 1201_ DPPKD 1206_ EKQGW 1211_ RHVRI 1216_ KQMGK 1221_ NASGQ 1226_ THYLS 1231_ LSGFE 1236_ LYGTV 1241_ NGVCE 1246_ DQLGK 1251_ AAKEA 1256_ EANLR 1261_ RQRRL 1266_ VRSQV 1271_ LKYMV 1276_ PGARV 1281_ IRGLD 1286_ WKWRD 1291_ QDGSP 1296_ QGEGT 1301_ VTGEL 1306_ HNGWI 1311_ DVTWD 1316_ AGGSN 1321_ SYRMG 1326_ AEGKF 1331_ DLKLA 1336_ PGYDP 1341_ DTVAS 1346_ PKPVS 1351_ STVSG 1356_ TTQSW 1361_ SSLVK 1366_ NNCPD 1371_ KTSAA 1376_ AGSSS 1381_ RKGSS 1386_ SSVCS 1391_ VASSS 1396_ DISLG 1401_ STKTE 1406_ RRSEI 1411_ VMEHS 1416_ IVSGA 1421_ DVHEP 1426_ IVVLS 1431_ SAENV 1436_ PQTEV 1441_ GSSSS 1446_ ASTST 1451_ LTAET 1456_ GSENA 1461_ ERKLG 1466_ PDSSV 1471_ RTPGE 1476_ SSAIS 1481_ MGIVS 1486_ VSSPD 1491_ VSSVS 1496_ ELTNK 1501_ EAASQ 1506_ RPLSS 1511_ SASNR 1516_ LSVSS 1521_ LLAAG 1526_ APMSS 1531_ SASVP 1536_ NLSSR 1541_ ETSSL 1546_ ESFVR 1551_ RVANI 1556_ ARTNA 1561_ TNNMN 1566_ LSRSS 1571_ SDNNT 1576_ NTLGR 1581_ NVMST 1586_ ATSPL 1591_ MGAQS 1596_ FPNLT 1601_ TPGTT 1606_ STVTM 1611_ STSSV 1616_ TSSSN 1621_ VATAT 1626_ TVLSV 1631_ GQSLS 1636_ NTLTT 1641_ SLTST 1646_ SSESD 1651_ TGQEA 1656_ EYSLY 1661_ DFLDS 1666_ CRAST 1671_ LLAEL 1676_ DDDED 1681_ LPEPD 1686_ EEDDE 1691_ NEDDN 1696_ QEDQE 1701_ YEEVM 1706_ ILRRP 1711_ SLQRR 1716_ AGSRS 1721_ DVTHH 1726_ AVTSQ 1731_ LPQVP 1736_ AGAGS 1741_ RPIGE 1746_ QEEEE 1751_ YETKG 1756_ GRRRT 1761_ WDDDY 1766_ VLKRQ 1771_ FSALV 1776_ PAFDP 1781_ RPGRT 1786_ NVQQT 1791_ TDLEI 1796_ PPPGT 1801_ PHSEL 1806_ LEEVE 1811_ CTPSP 1816_ RLALT 1821_ LKVTG 1826_ LGTTR 1831_ EVELP 1836_ LTNFR 1841_ STIFY 1846_ YVQKL 1851_ LQLSC 1856_ NGNVK 1861_ SDKLR 1866_ RIWEP 1871_ TYTIM 1876_ YREMK 1881_ DSDKE 1886_ KENGK 1891_ MGCWS 1896_ IEHVE 1901_ QYLGT 1906_ DELPK 1911_ NDLIT 1916_ YLQKN 1921_ ADAAF 1926_ LRHWK 1931_ LTGTN 1936_ KSIRK 1941_ NRNCS 1946_ QLIAA 1951_ YKDFC 1956_ EHGTK 1961_ SGLNQ 1966_ GAIST 1971_ LQSSD 1976_ ILNLT 1981_ KEQPQ 1986_ AKAGN 1991_ GQNSC 1996_ GVEDV 2001_ LQLLR 2006_ ILYIV 2011_ ASDPY 2016_ SRISQ 2021_ EDGDE 2026_ QPQFT 2031_ FPPDE 2036_ FTSKK 2041_ ITTKI 2046_ LQQIE 2051_ EPLAL 2056_ ASGAL 2061_ PDWCE 2066_ QLTSK 2071_ CPFLI 2076_ PFETR 2081_ QLYFT 2086_ CTAFG 2091_ ASRAI 2096_ VWLQN 2101_ RREAT 2106_ VERTR 2111_ TTSSV 2116_ RRDDP 2121_ GEFRV 2126_ GRLKH 2131_ ERVKV 2136_ PRGES 2141_ LMEWA 2146_ ENVMQ 2151_ IHADR 2156_ KSVLE 2161_ VEFLG 2166_ EEGTG 2171_ LGPTL 2176_ EFYAL 2181_ VAAEF 2186_ QRTDL 2191_ GAWLC 2196_ DDNFP 2201_ DDESR 2206_ HVDLG 2211_ GGLKP 2216_ PGYYV 2221_ QRSCG 2226_ LFTAP 2231_ FPQDS 2236_ DELER 2241_ ITKLF 2246_ HFLGI 2251_ FLAKC 2256_ IQDNR 2261_ LVDLP 2266_ ISKPF 2271_ FKLMC 2276_ MGDIK 2281_ SNMSK 2286_ LIYES 2291_ RGDRD 2296_ LHCTE 2301_ SQSEA 2306_ STEEG 2311_ HDSLS 2316_ VGSFE 2321_ EDSKS 2326_ EFILD 2331_ PPKPK 2336_ PPAWF 2341_ NGILT 2346_ WEDFE 2351_ LVNPH 2356_ RARFL 2361_ KEIKD 2366_ LAIKR 2371_ RQILS 2376_ NKGLS 2381_ EDEKN 2386_ TKLQE 2391_ LVLKN 2396_ PSGSG 2401_ PPLSI 2406_ EDLGL 2411_ NFQFC 2416_ PSSRI 2421_ YGFTA 2426_ VDLKP 2431_ SGEDE 2436_ MITMD 2441_ NAEEY 2446_ VDLMF 2451_ DFCMH 2456_ TGIQK 2461_ QMEAF 2466_ RDGFN 2471_ KVFPM 2476_ EKLSS 2481_ FSHEE 2486_ VQMIL 2491_ CGNQS 2496_ PSWAA 2501_ EDIIN 2506_ YTEPK 2511_ LGYTR 2516_ DSPGF 2521_ LRFVR 2526_ VLCGM 2531_ SSDER 2536_ KAFLQ 2541_ FTTGC 2546_ STLPP 2551_ GGLAN 2556_ LHPRL 2561_ TVVRK 2566_ VDATD 2571_ ASYPS 2576_ VNTCV 2581_ HYLKL 2586_ PEYSS 2591_ EEIMR 2596_ ERLLA 2601_ATMEK
1: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (PubMed:33711283). Mediates 'Lys-63'-linked polyubiquitination of HSP90AA1 which leads to its intracellular localization and reduced secretion (By similarity). Negatively regulating HSP90AA1 secretion in cranial mesenchyme cells may impair their emigration and may be essential for the correct development of the cranial neural folds and neural tube closure (By similarity). Catalyzes ubiquitination and degradation of ZNF622, an assembly factor for the ribosomal 60S subunit, in hematopoietic cells, thereby promoting hematopoietic stem cell renewal (PubMed:33711283)