Protein kinase C-binding protein 1 (Cutaneous T-cell lymphoma-associated antigen se14-3) (CTCL-associated antigen se14-3) (Rack7) (Zinc finger MYND domain-containing protein 8)
1_MDIST 6_ RSKDP 11_ GSAER 16_ TAQKR 21_ KFPSP 26_ PHSSN 31_ GHSPQ 36_ DTSTS 41_ PIKKK 46_ KKPGL 51_ LNSNN 56_ KEQSE 61_ LRHGP 66_ FYYMK 71_ QPLTT 76_ DPVDV 81_ VPQDG 86_ RNDFY 91_ CWVCH 96_ REGQV 101_ LCCEL 106_ CPRVY 111_ HAKCL 116_ RLTSE 121_ PEGDW 126_ FCPEC 131_ EKITV 136_ AECIE 141_ TQSKA 146_ MTMLT 151_ IEQLS 156_ YLLKF 161_ AIQKM 166_ KQPGT 171_ DAFQK 176_ PVPLE 181_ QHPDY 186_ AEYIF 191_ HPMDL 196_ CTLEK 201_ NAKKK 206_ MYGCT 211_ EAFLA 216_ DAKWI 221_ LHNCI 226_ IYNGG 231_ NHKLT 236_ QIAKV 241_ VIKIC 246_ EHEMN 251_ EIEVC 256_ PECYL 261_ AACQK 266_ RDNWF 271_ CEPCS 276_ NPHPL 281_ VWAKL 286_ KGFPF 291_ WPAKA 296_ LRDKD 301_ GQVDA 306_ RFFGQ 311_ HDRAW 316_ VPINN 321_ CYLMS 326_ KEIPF 331_ SVKKT 336_ KSIFN 341_ SAMQE 346_ MEVYV 351_ ENIRR 356_ KFGVF 361_ NYSPF 366_ RTPYT 371_ PNSQY 376_ QMLLD 381_ PTNPS 386_ AGTAK 391_ IDKQE 396_ KVKLN 401_ FDMTA 406_ SPKIL 411_ MSKPV 416_ LSGGT 421_ GRRIS 426_ LSDMP 431_ RSPMS 436_ TNSSV 441_ HTGSD 446_ VEQDA 451_ EKKAT 456_ SSHFS 461_ ASEES 466_ MDFLD 471_ KSTAS 476_ PASTK 481_ TGQAG 486_ SLSGS 491_ PKPFS 496_ PQLSA 501_ PITTK 506_ TDKTS 511_ TTGSI 516_ LNLNL 521_ DRSKA 526_ EMDLK 531_ ELSES 536_ VQQQS 541_ TPVPL 546_ ISPKR 551_ QIRSR 556_ FQLNL 561_ DKTIE 566_ SCKAQ 571_ LGINE 576_ ISEDV 581_ YTAVE 586_ HSDSE 591_ DSEKS 596_ DSSDS 601_ EYISD 606_ DEQKS 611_ KNEPE 616_ DTEDK 621_ EGCQM 626_ DKEPS 631_ AVKKK 636_ PKPTN 641_ PVEIK 646_ EELKS 651_ TSPAS 656_ EKADP 661_ GAVKD 666_ KASPE 671_ PEKDF 676_ SEKAK 681_ PSPHP 686_ IKDKL 691_ KGKDE 696_ TDSPT 701_ VHLGL 706_ DSDSE 711_ SELVI 716_ DLGED 721_ HSGRE 726_ GRKNK 731_ KEPKE 736_ PSPKQ 741_ DVVGK 746_ TPPST 751_ TVGSH 756_ SPPET 761_ PVLTR 766_ SSAQT 771_ SAAGA 776_ TATTS 781_ TSSTV 786_ TVTAP 791_ APAAT 796_ GSPVK 801_ KQRPL 806_ LPKET 811_ APAVQ 816_ RVVWN 821_ SSSKF 826_ QTSSQ 831_ KWHMQ 836_ KMQRQ 841_ QQQQQ 846_ QQNQQ 851_ QQPQS 856_ SQGTR 861_ YQTRQ 866_ AVKAV 871_ QQKEI 876_ TQSPS 881_ TSTIT 886_ LVTST 891_ QSSPL 896_ VTSSG 901_ SMSTL 906_ VSSVN 911_ ADLPI 916_ ATASA 921_ DVAAD 926_ IAKYT 931_ SKMMD 936_ AIKGT 941_ MTEIY 946_ NDLSK 951_ NTTGS 956_ TIAEI 961_ RRLRI 966_ EIEKL 971_ QWLHQ 976_ QELSE 981_ MKHNL 986_ ELTMA 991_ EMRQS 996_ LEQER 1001_ DRLIA 1006_ EVKKQ 1011_ LELEK 1016_ QQAVD 1021_ ETKKK 1026_ QWCAN 1031_ CKKEA 1036_ IFYCC 1041_ WNTSY 1046_ CDYPC 1051_ QQAHW 1056_ PEHMK 1061_ SCTQS 1066_ ATAPQ 1071_ QEADA 1076_ EVNTE 1081_ TLNKS 1086_ SQGSS 1091_ SSTQS 1096_ APSET 1101_ ASASK 1106_ EKETS 1111_ AEKSK 1116_ ESGST 1121_ LDLSG 1126_ SRETP 1131_ SSILL 1136_ GSNQG 1141_ SDHSR 1146_ SNKSS 1151_ WSSSD 1156_ EKRGS 1161_ TRSDH 1166_ NTSTS 1171_ TKSLL 1176_ PKESR 1181_LDTFW
1: Chromatin reader that recognizes dual histone modifications such as histone H3.1 dimethylated at 'Lys-36' and histone H4 acetylated at 'Lys-16' (H3.1K36me2-H4K16ac) and histone H3 methylated at 'Lys-4' and histone H4 acetylated at 'Lys-14' (H3K4me1-H3K14ac) (PubMed:26655721, PubMed:27477906, PubMed:31965980, PubMed:36064715). May act as a transcriptional corepressor for KDM5D by recognizing the dual histone signature H3K4me1-H3K14ac (PubMed:27477906). May also act as a transcriptional corepressor for KDM5C and EZH2 (PubMed:33323928). Recognizes acetylated histone H4 and recruits the NuRD chromatin remodeling complex to damaged chromatin for transcriptional repression and double-strand break repair by homologous recombination (PubMed:25593309, PubMed:27732854, PubMed:30134174). Also activates transcription elongation by RNA polymerase II through recruiting the P-TEFb complex to target promoters (PubMed:26655721, PubMed:30134174). Localizes to H3.1K36me2-H4K16ac marks at all-trans-retinoic acid (ATRA)-responsive genes and positively regulates their expression (PubMed:26655721). Promotes neuronal differentiation by associating with regulatory regions within the MAPT gene, to enhance transcription of a protein-coding MAPT isoform and suppress the non-coding MAPT213 isoform (PubMed:30134174, PubMed:35916866, PubMed:36064715). Suppresses breast cancer, and prostate cancer cell invasion and metastasis (PubMed:27477906, PubMed:31965980, PubMed:33323928)