Frizzled-4 (Fz-4) (hFz4) (FzE4) (CD antigen CD344)
1_MAWRG 6_ AGPSV 11_ PGAPG 16_ GVGLS 21_ LGLLL 26_ QLLLL 31_ LGPAR 36_ GFGDE 41_ EERRC 46_ DPIRI 51_ SMCQN 56_ LGYNV 61_ TKMPN 66_ LVGHE 71_ LQTDA 76_ ELQLT 81_ TFTPL 86_ IQYGC 91_ SSQLQ 96_ FFLCS 101_ VYVPM 106_ CTEKI 111_ NIPIG 116_ PCGGM 121_ CLSVK 126_ RRCEP 131_ VLKEF 136_ GFAWP 141_ ESLNC 146_ SKFPP 151_ QNDHN 156_ HMCME 161_ GPGDE 166_ EVPLP 171_ HKTPI 176_ QPGEE 181_ CHSVG 186_ TNSDQ 191_ YIWVK 196_ RSLNC 201_ VLKCG 206_ YDAGL 211_ YSRSA 216_ KEFTD 221_ IWMAV 226_ WASLC 231_ FISTA 236_ FTVLT 241_ FLIDS 246_ SRFSY 251_ PERPI 256_ IFLSM 261_ CYNIY 266_ SIAYI 271_ VRLTV 276_ GRERI 281_ SCDFE 286_ EAAEP 291_ VLIQE 296_ GLKNT 301_ GCAII 306_ FLLMY 311_ FFGMA 316_ SSIWW 321_ VILTL 326_ TWFLA 331_ AGLKW 336_ GHEAI 341_ EMHSS 346_ YFHIA 351_ AWAIP 356_ AVKTI 361_ VILIM 366_ RLVDA 371_ DELTG 376_ LCYVG 381_ NQNLD 386_ ALTGF 391_ VVAPL 396_ FTYLV 401_ IGTLF 406_ IAAGL 411_ VALFK 416_ IRSNL 421_ QKDGT 426_ KTDKL 431_ ERLMV 436_ KIGVF 441_ SVLYT 446_ VPATC 451_ VIACY 456_ FYEIS 461_ NWALF 466_ RYSAD 471_ DSNMA 476_ VEMLK 481_ IFMSL 486_ LVGIT 491_ SGMWI 496_ WSAKT 501_ LHTWQ 506_ KCSNR 511_ LVNSG 516_ KVKRE 521_ KRGNG 526_ WVKPG 531_KGSET
1: Receptor for Wnt proteins (PubMed:30135577). Most frizzled receptors are coupled to the beta-catenin (CTNNB1) canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin (CTNNB1) and activation of Wnt target genes (PubMed:30135577). Plays a critical role in retinal vascularization by acting as a receptor for Wnt proteins and norrin (NDP) (By similarity). In retina, it can be activated by Wnt protein-binding and also by Wnt-independent signaling via binding of norrin (NDP), promoting in both cases beta-catenin (CTNNB1) accumulation and stimulation of LEF/TCF-mediated transcriptional programs (By similarity). A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues