Coronin-1C (Coronin-3) (hCRNN4)
1_MRRVV 6_ RQSKF 11_ RHVFG 16_ QAVKN 21_ DQCYD 26_ DIRVS 31_ RVTWD 36_ SSFCA 41_ VNPRF 46_ VAIII 51_ EASGG 56_ GAFLV 61_ LPLHK 66_ TGRID 71_ KSYPT 76_ VCGHT 81_ GPVLD 86_ IDWCP 91_ HNDQV 96_ IASGS 101_ EDCTV 106_ MVWQI 111_ PENGL 116_ TLSLT 121_ EPVVI 126_ LEGHS 131_ KRVGI 136_ VAWHP 141_ TARNV 146_ LLSAG 151_ CDNAI 156_ IIWNV 161_ GTGEA 166_ LINLD 171_ DMHSD 176_ MIYNV 181_ SWNRN 186_ GSLIC 191_ TASKD 196_ KKVRV 201_ IDPRK 206_ QEIVA 211_ EKEKA 216_ HEGAR 221_ PMRAI 226_ FLADG 231_ NVFTT 236_ GFSRM 241_ SERQL 246_ ALWNP 251_ KNMQE 256_ PIALH 261_ EMDTS 266_ NGVLL 271_ PFYDP 276_ DTSII 281_ YLCGK 286_ GDSSI 291_ RYFEI 296_ TDESP 301_ YVHYL 306_ NTFSS 311_ KEPQR 316_ GMGYM 321_ PKRGL 326_ DVNKC 331_ EIARF 336_ FKLHE 341_ RKCEP 346_ IIMTV 351_ PRKSD 356_ LFQDD 361_ LYPDT 366_ AGPEA 371_ ALEAE 376_ EWFEG 381_ KNADP 386_ ILISL 391_ KHGYI 396_ PGKNR 401_ DLKVV 406_ KKNIL 411_ DSKPT 416_ ANKKC 421_ DLISI 426_ PKKTT 431_ DTASV 436_ QNEAK 441_ LDEIL 446_ KEIKS 451_ IKDTI 456_ CNQDE 461_ RISKL 466_EQQMA
1: Plays a role in directed cell migration by regulating the activation and subcellular location of RAC1 (PubMed:25074804, PubMed:25925950). Increases the presence of activated RAC1 at the leading edge of migrating cells (PubMed:25074804, PubMed:25925950). Required for normal organization of the cytoskeleton, including the actin cytoskeleton, microtubules and the vimentin intermediate filaments (By similarity). Plays a role in endoplasmic reticulum-associated endosome fission: localizes to endosome membrane tubules and promotes recruitment of TMCC1, leading to recruitment of the endoplasmic reticulum to endosome tubules for fission (PubMed:30220460). Endosome membrane fission of early and late endosomes is essential to separate regions destined for lysosomal degradation from carriers to be recycled to the plasma membrane (PubMed:30220460). Required for normal cell proliferation, cell migration, and normal formation of lamellipodia (By similarity). Required for normal distribution of mitochondria within cells (By similarity)
2: Involved in myogenic differentiation