Heat shock factor protein 4 (HSF 4) (hHSF4) (Heat shock transcription factor 4) (HSTF 4)
1_MQEAP 6_ AALPT 11_ EPGPS 16_ PVPAF 21_ LGKLW 26_ ALVGD 31_ PGTDH 36_ LIRWS 41_ PSGTS 46_ FLVSD 51_ QSRFA 56_ KEVLP 61_ QYFKH 66_ SNMAS 71_ FVRQL 76_ NMYGF 81_ RKVVS 86_ IEQGG 91_ LLRPE 96_ RDHVE 101_ FQHPS 106_ FVRGR 111_ EQLLE 116_ RVRRK 121_ VPALR 126_ GDDGR 131_ WRPED 136_ LGRLL 141_ GEVQA 146_ LRGVQ 151_ ESTEA 156_ RLREL 161_ RQQNE 166_ ILWRE 171_ VVTLR 176_ QSHGQ 181_ QHRVI 186_ GKLIQ 191_ CLFGP 196_ LQAGP 201_ SNAGG 206_ KRKLS 211_ LMLDE 216_ GSSCP 221_ TPAKF 226_ NTCPL 231_ PGALL 236_ QDPYF 241_ IQSPL 246_ PETNL 251_ GLSPH 256_ RARGP 261_ IISDI 266_ PEDSP 271_ SPEGT 276_ RLSPS 281_ SDGRR 286_ EKGLA 291_ LLKEE 296_ PASPG 301_ GDGEA 306_ GLALA 311_ PNECD 316_ FCVTA 321_ PPPLP 326_ VAVVQ 331_ AILEG 336_ KGSFS 341_ PEGPR 346_ NAQQP 351_ EPGDP 356_ REIPD 361_ RGPLG 366_ LESGD 371_ RSPES 376_ LLPPM 381_ LLQPP 386_ QESVE 391_ PAGPL 396_ DVLGP 401_ SLQGR 406_ EWTLM 411_ DLDME 416_ LSLMQ 421_ PLVPE 426_ RGEPE 431_ LAVKG 436_ LNSPS 441_ PGKDP 446_ TLGAP 451_ LLLDV 456_ QAALG 461_ GPALG 466_ LPGAL 471_ TIYST 476_ PESRT 481_ ASYLG 486_PEASP
1: Heat-shock transcription factor that specifically binds heat shock promoter elements (HSE) (PubMed:22587838, PubMed:23507146). Required for denucleation and organelle rupture and degradation that occur during eye lens terminal differentiation, when fiber cells that compose the lens degrade all membrane-bound organelles in order to provide lens with transparency to allow the passage of light (By similarity). In this process, may regulate denucleation of lens fiber cells in part by activating DNASE2B transcription (By similarity). May be involved in DNA repair through the transcriptional regulation of RAD51 (PubMed:22587838). May up-regulate p53/TP53 protein in eye lens fiber cells, possibly through protein stabilization (PubMed:28981088). In the eye lens, controls the expression of alpha-crystallin B chain/CRYAB and consequently may be involved in the regulation of lysosomal acidification (By similarity)
2: Transcriptional repressor
3: Transcriptional activator