E3 ubiquitin-protein ligase CBL-C (EC 2.3.2.27) (RING finger protein 57) (RING-type E3 ubiquitin transferase CBL-C) (SH3-binding protein CBL-3) (SH3-binding protein CBL-C) (Signal transduction protein CBL-C)
1_MALAV 6_ APWGR 11_ QWEEA 16_ RALGR 21_ AVRML 26_ QRLEE 31_ QCVDP 36_ RLSVS 41_ PPSLR 46_ DLLPR 51_ TAQLL 56_ REVAH 61_ SRRAA 66_ GGGGP 71_ GGPGG 76_ SGDFL 81_ LIYLA 86_ NLEAK 91_ SRQVA 96_ ALLPP 101_ RGRRS 106_ ANDEL 111_ FRAGS 116_ RLRRQ 121_ LAKLA 126_ IIFSH 131_ MHAEL 136_ HALFP 141_ GGKYC 146_ GHMYQ 151_ LTKAP 156_ AHTFW 161_ RESCG 166_ ARCVL 171_ PWAEF 176_ ESLLG 181_ TCHPV 186_ EPGCT 191_ ALALR 196_ TTIDL 201_ TCSGH 206_ VSIFE 211_ FDVFT 216_ RLFQP 221_ WPTLL 226_ KNWQL 231_ LAVNH 236_ PGYMA 241_ FLTYD 246_ EVQER 251_ LQACR 256_ DKPGS 261_ YIFRP 266_ SCTRL 271_ GQWAI 276_ GYVSS 281_ DGSIL 286_ QTIPA 291_ NKPLS 296_ QVLLE 301_ GQKDG 306_ FYLYP 311_ DGKTH 316_ NPDLT 321_ ELGQA 326_ EPQQR 331_ IHVSE 336_ EQLQL 341_ YWAMD 346_ STFEL 351_ CKICA 356_ ESNKD 361_ VKIEP 366_ CGHLL 371_ CSCCL 376_ AAWQH 381_ SDSQT 386_ CPFCR 391_ CEIKG 396_ WEAVS 401_ IYQFH 406_ GQATA 411_ EDSGN 416_ SSDQE 421_ GRELE 426_ LGQVP 431_ LSAPP 436_ LPPRP 441_ DLPPR 446_ KPRNA 451_ QPKVR 456_ LLKGN 461_ SPPAA 466_LGPQD
1: Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Functionally coupled with the E2 ubiquitin-protein ligases UB2D1, UB2D2 and UB2D3. Regulator of EGFR mediated signal transduction; upon EGF activation, ubiquitinates EGFR. Isoform 1, but not isoform 2, inhibits EGF stimulated MAPK1 activation. Promotes ubiquitination of SRC phosphorylated at 'Tyr-419'. In collaboration with CD2AP may act as regulatory checkpoint for Ret signaling by modulating the rate of RET degradation after ligand activation; CD2AP converts it from an inhibitor to a promoter of RET degradation; the function limits the potency of GDNF on neuronal survival