Targeting protein for Xklp2 (Differentially expressed in cancerous and non-cancerous lung cells 2) (DIL-2) (Hepatocellular carcinoma-associated antigen 519) (Hepatocellular carcinoma-associated antigen 90) (Protein fls353) (Restricted expression proliferation-associated protein 100) (p100)
1_MSQVK 6_ SSYSY 11_ DAPSD 16_ FINFS 21_ SLDDE 26_ GDTQN 31_ IDSWF 36_ EEKAN 41_ LENKL 46_ LGKNG 51_ TGGLF 56_ QGKTP 61_ LRKAN 66_ LQQAI 71_ VTPLK 76_ PVDNT 81_ YYKEA 86_ EKENL 91_ VEQSI 96_ PSNAC 101_ SSLEV 106_ EAAIS 111_ RKTPA 116_ QPQRR 121_ SLRLS 126_ AQKDL 131_ EQKEK 136_ HHVKM 141_ KAKRC 146_ ATPVI 151_ IDEIL 156_ PSKKM 161_ KVSNN 166_ KKKPE 171_ EEGSA 176_ HQDTA 181_ EKNAS 186_ SPEKA 191_ KGRHT 196_ VPCMP 201_ PAKQK 206_ FLKST 211_ EEQEL 216_ EKSMK 221_ MQQEV 226_ VEMRK 231_ KNEEF 236_ KKLAL 241_ AGIGQ 246_ PVKKS 251_ VSQVT 256_ KSVDF 261_ HFRTD 266_ ERIKQ 271_ HPKNQ 276_ EEYKE 281_ VNFTS 286_ ELRKH 291_ PSSPA 296_ RVTKG 301_ CTIVK 306_ PFNLS 311_ QGKKR 316_ TFDET 321_ VSTYV 326_ PLAQQ 331_ VEDFH 336_ KRTPN 341_ RYHLR 346_ SKKDD 351_ INLLP 356_ SKSSV 361_ TKICR 366_ DPQTP 371_ VLQTK 376_ HRARA 381_ VTCKS 386_ TAELE 391_ AEELE 396_ KLQQY 401_ KFKAR 406_ ELDPR 411_ ILEGG 416_ PILPK 421_ KPPVK 426_ PPTEP 431_ IGFDL 436_ EIEKR 441_ IQERE 446_ SKKKT 451_ EDEHF 456_ EFHSR 461_ PCPTK 466_ ILEDV 471_ VGVPE 476_ KKVLP 481_ ITVPK 486_ SPAFA 491_ LKNRI 496_ RMPTK 501_ EDEEE 506_ DEPVV 511_ IKAQP 516_ VPHYG 521_ VPFKP 526_ QIPEA 531_ RTVEI 536_ CPFSF 541_ DSRDK 546_ ERQLQ 551_ KEKKI 556_ KELQK 561_ GEVPK 566_ FKALP 571_ LPHFD 576_ TINLP 581_ EKKVK 586_ NVTQI 591_ EPFCL 596_ ETDRR 601_ GALKA 606_ QTWKH 611_ QLEEE 616_ LRQQK 621_ EAACF 626_ KARPN 631_ TVISQ 636_ EPFVP 641_ KKEKK 646_ SVAEG 651_ LSGSL 656_ VQEPF 661_ QLATE 666_ KRAKE 671_ RQELE 676_ KRMAE 681_ VEAQK 686_ AQQLE 691_ EARLQ 696_ EEEQK 701_ KEELA 706_ RLRRE 711_ LVHKA 716_ NPIRK 721_ YQGLE 726_ IKSSD 731_ QPLTV 736_ PVSPK 741_FSTRF
1: Spindle assembly factor required for normal assembly of mitotic spindles. Required for normal assembly of microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation. Mediates AURKA localization to spindle microtubules (PubMed:18663142, PubMed:19208764, PubMed:37728657). Activates AURKA by promoting its autophosphorylation at 'Thr-288' and protects this residue against dephosphorylation (PubMed:18663142, PubMed:19208764). TPX2 is inactivated upon binding to importin-alpha (PubMed:26165940). At the onset of mitosis, GOLGA2 interacts with importin-alpha, liberating TPX2 from importin-alpha, allowing TPX2 to activate AURKA kinase and stimulate local microtubule nucleation (PubMed:26165940)