Frizzled-10 (Fz-10) (hFz10) (FzE7) (CD antigen CD350)
1_MQRPG 6_ PRLWL 11_ VLQVM 16_ GSCAA 21_ ISSMD 26_ MERPG 31_ DGKCQ 36_ PIEIP 41_ MCKDI 46_ GYNMT 51_ RMPNL 56_ MGHEN 61_ QREAA 66_ IQLHE 71_ FAPLV 76_ EYGCH 81_ GHLRF 86_ FLCSL 91_ YAPMC 96_ TEQVS 101_ TPIPA 106_ CRVMC 111_ EQARL 116_ KCSPI 121_ MEQFN 126_ FKWPD 131_ SLDCR 136_ KLPNK 141_ NDPNY 146_ LCMEA 151_ PNNGS 156_ DEPTR 161_ GSGLF 166_ PPLFR 171_ PQRPH 176_ SAQEH 181_ PLKDG 186_ GPGRG 191_ GCDNP 196_ GKFHH 201_ VEKSA 206_ SCAPL 211_ CTPGV 216_ DVYWS 221_ REDKR 226_ FAVVW 231_ LAIWA 236_ VLCFF 241_ SSAFT 246_ VLTFL 251_ IDPAR 256_ FRYPE 261_ RPIIF 266_ LSMCY 271_ CVYSV 276_ GYLIR 281_ LFAGA 286_ ESIAC 291_ DRDSG 296_ QLYVI 301_ QEGLE 306_ STGCT 311_ LVFLV 316_ LYYFG 321_ MASSL 326_ WWVVL 331_ TLTWF 336_ LAAGK 341_ KWGHE 346_ AIEAN 351_ SSYFH 356_ LAAWA 361_ IPAVK 366_ TILIL 371_ VMRRV 376_ AGDEL 381_ TGVCY 386_ VGSMD 391_ VNALT 396_ GFVLI 401_ PLACY 406_ LVIGT 411_ SFILS 416_ GFVAL 421_ FHIRR 426_ VMKTG 431_ GENTD 436_ KLEKL 441_ MVRIG 446_ LFSVL 451_ YTVPA 456_ TCVIA 461_ CYFYE 466_ RLNMD 471_ YWKIL 476_ AAQHK 481_ CKMNN 486_ QTKTL 491_ DCLMA 496_ ASIPA 501_ VEIFM 506_ VKIFM 511_ LLVVG 516_ ITSGM 521_ WIWTS 526_ KTLQS 531_ WQQVC 536_ SRRLK 541_ KKSRR 546_ KPASV 551_ ITSGG 556_ IYKKA 561_ QHPQK 566_ THHGK 571_ YEIPA 576_QSPTC
1: Receptor for Wnt proteins. Functions in the canonical Wnt/beta-catenin signaling pathway (By similarity). The canonical Wnt/beta-catenin signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues (Probable)