Ras-related protein Rab-26
1_MSRKK 6_ TPKSK 11_ GASTP 16_ AASTL 21_ PTANG 26_ ARPAR 31_ SGTAL 36_ SGPDA 41_ PPNGP 46_ LQPGR 51_ PSLGG 56_ GVDFY 61_ DVAFK 66_ VMLVG 71_ DSGVG 76_ KTCLL 81_ VRFKD 86_ GAFLA 91_ GTFIS 96_ TVGID 101_ FRNKV 106_ LDVDG 111_ VKVKL 116_ QMWDT 121_ AGQER 126_ FRSVT 131_ HAYYR 136_ DAHAL 141_ LLLYD 146_ VTNKA 151_ SFDNI 156_ QAWLT 161_ EIHEY 166_ AQHDV 171_ ALMLL 176_ GNKVD 181_ SAHER 186_ VVKRE 191_ DGEKL 196_ AKEYG 201_ LPFME 206_ TSAKT 211_ GLNVD 216_ LAFTA 221_ IAKEL 226_ KQRSM 231_ KAPSE 236_ PRFRL 241_ HDYVK 246_ REGRG 251_ASCCR
1: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). RAB26 mediates transport of ADRA2A and ADRA2B from the Golgi to the cell membrane (PubMed:23105096). Plays a role in the maturation of zymogenic granules and in pepsinogen secretion in the stomach (PubMed:20038531). Plays a role in the secretion of amylase from acinar granules in the parotid gland (By similarity)