RING finger protein 112 (EC 2.3.2.27) (Brain finger protein) (Zinc finger protein 179)
1_MPRPA 6_ LSVTS 11_ FCHRL 16_ GKRER 21_ KQSFM 26_ GNSGN 31_ SWSHT 36_ PFPKL 41_ ELGLG 46_ PQPMA 51_ PRELP 56_ TCSIC 61_ LERLR 66_ DPISL 71_ DCGHD 76_ FCIRC 81_ FSTHR 86_ LPGCE 91_ PPCCP 96_ ECRKI 101_ CKQKR 106_ GLRSL 111_ GEKMK 116_ LLPQR 121_ PLPPA 126_ LQETC 131_ PVRAE 136_ PLLLV 141_ RINAS 146_ GGLIL 151_ RMGAI 156_ NRCLK 161_ HPLAR 166_ DTPVC 171_ LLAVL 176_ GEQHS 181_ GKSFL 186_ LNHLL 191_ QGLPG 196_ LESGE 201_ GGRPR 206_ GGEAS 211_ LQGCR 216_ WGANG 221_ LARGI 226_ WMWSH 231_ PFLLG 236_ KEGKK 241_ VAVFL 246_ VDTGD 251_ AMSPE 256_ LSRET 261_ RIKLC 266_ ALTTM 271_ LSSYQ 276_ ILSTS 281_ QELKD 286_ TDLDY 291_ LEMFV 296_ HVAEV 301_ MGKHY 306_ GMVPI 311_ QHLDL 316_ LVRDS 321_ SHPNK 326_ AGQGH 331_ VGNIF 336_ QRLSG 341_ RYPKV 346_ QELLQ 351_ GKRAR 356_ CCLLP 361_ APGRR 366_ RMNQG 371_ HASPG 376_ DTDDD 381_ FRHLL 386_ GAYVS 391_ DVLSA 396_ APQHA 401_ KSRCQ 406_ GYWNE 411_ GRAVA 416_ RGDRR 421_ LLTGQ 426_ QLAQE 431_ IKNLS 436_ GWMGR 441_ TGPGF 446_ TSPDE 451_ MAAQL 456_ HDLRK 461_ VEAAK 466_ REFEE 471_ YVRQQ 476_ DVATK 481_ RIFSA 486_ LRVLP 491_ DTMRN 496_ LLSTQ 501_ KDAIL 506_ ARHGV 511_ ALLCK 516_ GRDQT 521_ LEALE 526_ AELQA 531_ TAKAF 536_ MDSYT 541_ MRFCG 546_ HLAAV 551_ GGAVG 556_ AGLMG 561_ LAGGV 566_ VGAGM 571_ AAAAL 576_ AAEAG 581_ MVAAG 586_ AAVGA 591_ TGAAV 596_ VGGGV 601_ GAGLA 606_ ATVGC 611_ MEKEE 616_ DERLL 621_ EGDRE 626_PLLQE
1: E3 ubiquitin-protein ligase that plays an important role in neuronal differentiation, including neurogenesis and gliogenesis, during brain development. During embryonic development initiates neuronal differentiation by inducing cell cycle arrest at the G0/G1 phase through up-regulation of cell-cycle regulatory proteins (PubMed:28684796). Plays a role not only in the fetal period during the development of the nervous system, but also in the adult brain, where it is involved in the maintenance of neural functions and protection of the nervous tissue cells from oxidative stress-induced damage. Exhibits GTPase and E3 ubiquitin-protein ligase activities. Regulates dendritic spine density and synaptic neurotransmission; its ability to hydrolyze GTP is involved in the maintenance of dendritic spine density (By similarity)