A-kinase anchor protein 8-like (AKAP8-like protein) (Helicase A-binding protein 95) (HAP95) (Homologous to AKAP95 protein) (HA95) (Neighbor of A-kinase-anchoring protein 95) (Neighbor of AKAP95)
1_MSYTG 6_ FVQGS 11_ ETTLQ 16_ STYSD 21_ TSAQP 26_ TCDYG 31_ YGTWN 36_ SGTNR 41_ GYEGY 46_ GYGYG 51_ YGQDN 56_ TTNYG 61_ YGMAT 66_ SHSWE 71_ MPSSD 76_ TNANT 81_ SASGS 86_ ASADS 91_ VLSRI 96_ NQRLD 101_ MVPHL 106_ ETDMM 111_ QGGVY 116_ GSGGE 121_ RYDSY 126_ ESCDS 131_ RAVLS 136_ ERDLY 141_ RSGYD 146_ YSELD 151_ PEMEM 156_ AYEGQ 161_ YDAYR 166_ DQFRM 171_ RGNDT 176_ FGPRA 181_ QGWAR 186_ DARSG 191_ RPMAS 196_ GYGRM 201_ WEDPM 206_ GARGQ 211_ CMSGA 216_ SRLPS 221_ LFSQN 226_ IIPEY 231_ GMFQG 236_ MRGGG 241_ AFPGG 246_ SRFGF 251_ GFGNG 256_ MKQMR 261_ RTWKT 266_ WTTAD 271_ FRTKK 276_ KKRKQ 281_ GGSPD 286_ EPDSK 291_ ATRTD 296_ CSDNS 301_ DSDND 306_ EGTEG 311_ EATEG 316_ LEGTE 321_ AVEKG 326_ SRVDG 331_ EDEEG 336_ KEDGR 341_ EEGKE 346_ DPEKG 351_ ALTTQ 356_ DENGQ 361_ TKRKL 366_ QAGKK 371_ SQDKQ 376_ KKRQR 381_ DRMVE 386_ RIQFV 391_ CSLCK 396_ YRTFY 401_ EDEMA 406_ SHLDS 411_ KFHKE 416_ HFKYV 421_ GTKLP 426_ KQTAD 431_ FLQEY 436_ VTNKT 441_ KKTEE 446_ LRKTV 451_ EDLDG 456_ LIQQI 461_ YRDQD 466_ LTQEI 471_ AMEHF 476_ VKKVE 481_ AAHCA 486_ ACDLF 491_ IPMQF 496_ GIIQK 501_ HLKTM 506_ DHNRN 511_ RRLMM 516_ EQSKK 521_ SSLMV 526_ ARSIL 531_ NNKLI 536_ SKKLE 541_ RYLKG 546_ ENPFT 551_ DSPEE 556_ EKEQE 561_ EAEGG 566_ ALDEG 571_ AQGEA 576_ AGISE 581_ GAEGV 586_ PAQPP 591_ VPPEP 596_ APGAV 601_ SPPPP 606_ PPPEE 611_ EEEGA 616_ VPLLG 621_ GALQR 626_ QIRGI 631_ PGLDV 636_ EDDEE 641_GGGGA
1: Could play a role in constitutive transport element (CTE)-mediated gene expression by association with DHX9. Increases CTE-dependent nuclear unspliced mRNA export (PubMed:10748171, PubMed:11402034). Proposed to target PRKACA to the nucleus but does not seem to be implicated in the binding of regulatory subunit II of PKA (PubMed:10761695, PubMed:11884601). May be involved in nuclear envelope breakdown and chromatin condensation. May be involved in anchoring nuclear membranes to chromatin in interphase and in releasing membranes from chromating at mitosis (PubMed:11034899). May regulate the initiation phase of DNA replication when associated with TMPO isoform Beta (PubMed:12538639). Required for cell cycle G2/M transition and histone deacetylation during mitosis. In mitotic cells recruits HDAC3 to the vicinity of chromatin leading to deacetylation and subsequent phosphorylation at 'Ser-10' of histone H3; in this function seems to act redundantly with AKAP8 (PubMed:16980585). May be involved in regulation of pre-mRNA splicing (PubMed:17594903)
2: (Microbial infection) In case of EBV infection, may target PRKACA to EBNA-LP-containing nuclear sites to modulate transcription from specific promoters
3: (Microbial infection) Can synergize with DHX9 to activate the CTE-mediated gene expression of type D retroviruses
4: (Microbial infection) In case of HIV-1 infection, involved in the DHX9-promoted annealing of host tRNA(Lys3) to viral genomic RNA as a primer in reverse transcription; in vitro negatively regulates DHX9 annealing activity