Transcription factor MafF (U-Maf) (V-maf musculoaponeurotic fibrosarcoma oncogene homolog F)
1_MSVDP 6_ LSSKA 11_ LKIKR 16_ ELSEN 21_ TPHLS 26_ DEALM 31_ GLSVR 36_ ELNRH 41_ LRGLS 46_ AEEVT 51_ RLKQR 56_ RRTLK 61_ NRGYA 66_ ASCRV 71_ KRVCQ 76_ KEELQ 81_ KQKSE 86_ LEREV 91_ DKLAR 96_ ENAAM 101_ RLELD 106_ ALRGK 111_ CEALQ 116_ GFARS 121_ VAAAR 126_ GPATL 131_ VAPAS 136_ VITIV 141_ KSTPG 146_ SGSGP 151_ AHGPD 156_PAHGP
1: Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves (PubMed:8932385). However, they seem to serve as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins, such as NFE2L1/NRF1, and recruiting them to specific DNA-binding sites. Interacts with the upstream promoter region of the oxytocin receptor gene (PubMed:16549056, PubMed:8932385). May be a transcriptional enhancer in the up-regulation of the oxytocin receptor gene at parturition (PubMed:10527846)