Matrix metalloproteinase-17 (MMP-17) (EC 3.4.24.-) (Membrane-type matrix metalloproteinase 4) (MT-MMP 4) (MTMMP4) (Membrane-type-4 matrix metalloproteinase) (MT4-MMP) (MT4MMP)
1_MRRRA 6_ ARGPG 11_ PPPPG 16_ PGLSR 21_ LPLPL 26_ LLLLA 31_ LGTRG 36_ GCAAP 41_ APAPR 46_ AEDLS 51_ LGVEW 56_ LSRFG 61_ YLPPA 66_ DPTTG 71_ QLQTQ 76_ EELSK 81_ AITAM 86_ QQFGG 91_ LEATG 96_ ILDEA 101_ TLALM 106_ KTPRC 111_ SLPDL 116_ PVLTQ 121_ ARRRR 126_ QAPAP 131_ TKWNK 136_ RNLSW 141_ RVRTF 146_ PRDSP 151_ LGHDT 156_ VRALM 161_ YYALK 166_ VWSDI 171_ APLNF 176_ HEVAG 181_ SAADI 186_ QIDFS 191_ KADHN 196_ DGYPF 201_ DGPGG 206_ TVAHA 211_ FFPGH 216_ HHTAG 221_ DTHFD 226_ DDEAW 231_ TFRSS 236_ DAHGM 241_ DLFAV 246_ AVHEF 251_ GHAIG 256_ LSHVA 261_ AAHSI 266_ MRPYY 271_ QGPVG 276_ DPLRY 281_ GLPYE 286_ DKVRV 291_ WQLYG 296_ VRESV 301_ SPTAQ 306_ PEEPP 311_ LLPEP 316_ PDNRS 321_ SAPPR 326_ KDVPH 331_ RCSTH 336_ FDAVA 341_ QIRGE 346_ AFFFK 351_ GKYFW 356_ RLTRD 361_ RHLVS 366_ LQPAQ 371_ MHRFW 376_ RGLPL 381_ HLDSV 386_ DAVYE 391_ RTSDH 396_ KIVFF 401_ KGDRY 406_ WVFKD 411_ NNVEE 416_ GYPRP 421_ VSDFS 426_ LPPGG 431_ IDAAF 436_ SWAHN 441_ DRTYF 446_ FKDQL 451_ YWRYD 456_ DHTRH 461_ MDPGY 466_ PAQSP 471_ LWRGV 476_ PSTLD 481_ DAMRW 486_ SDGAS 491_ YFFRG 496_ QEYWK 501_ VLDGE 506_ LEVAP 511_ GYPQS 516_ TARDW 521_ LVCGD 526_ SQADG 531_ SVAAG 536_ VDAAE 541_ GPRAP 546_ PGQHD 551_ QSRSE 556_ DGYEV 561_ CSCTS 566_ GASSP 571_ PGAPG 576_ PLVAA 581_ TMLLL 586_ LPPLS 591_ PGALW 596_TAAQA
1: Endopeptidase that degrades various components of the extracellular matrix, such as fibrin. May be involved in the activation of membrane-bound precursors of growth factors or inflammatory mediators, such as tumor necrosis factor-alpha. May also be involved in tumoral process. Cleaves pro-TNF-alpha at the '74-Ala-|-Gln-75' site. Not obvious if able to proteolytically activate progelatinase A. Does not hydrolyze collagen types I, II, III, IV and V, gelatin, fibronectin, laminin, decorin nor alpha1-antitrypsin