Calcium load-activated calcium channel (CLAC channel) (Transmembrane and coiled-coil domain-containing protein 1) (Transmembrane and coiled-coil domains protein 4) (Xenogeneic cross-immune protein PCIA3)
1_MPRKR 6_ KCDLR 11_ AVRVG 16_ LLLGG 21_ GGVYG 26_ SRFRF 31_ TFPGC 36_ RALSP 41_ WRVRV 46_ QRRRC 51_ EMSTM 56_ FADTL 61_ LIVFI 66_ SVCTA 71_ LLAEG 76_ ITWVL 81_ VYRTD 86_ KYKRL 91_ KAEVE 96_ KQSKK 101_ LEKKK 106_ ETITE 111_ SAGRQ 116_ QKKKI 121_ ERQEE 126_ KLKNN 131_ NRDLS 136_ MVRMK 141_ SMFAI 146_ GFCFT 151_ ALMGM 156_ FNSIF 161_ DGRVV 166_ AKLPF 171_ TPLSY 176_ IQGLS 181_ HRNLL 186_ GDDTT 191_ DCSFI 196_ FLYIL 201_ CTMSI 206_ RQNIQ 211_ KILGL 216_ APSRA 221_ ATKQA 226_ GGFLG 231_PPPPS
1: Endoplasmic reticulum (ER) calcium-selective channel preventing intracellular Ca2(+) stores from overfilling and maintaining calcium homeostasis in the ER (PubMed:27212239). In response to endoplasmic reticulum (ER) Ca2(+) overloading, assembles into a homotetramer, forming a functional calcium-selective channel facilitating Ca2(+) release (PubMed:27212239). Mediates ER Ca2(+) homeostasis in osteoblasts and plays a key role in bone formation, via the CaMKII-HDAC4-RUNX2 signaling axis (By similarity). Component of the multi-pass translocon (MPT) complex that mediates insertion of multi-pass membrane proteins into the lipid bilayer of membranes (PubMed:32820719, PubMed:36261522). The MPT complex takes over after the SEC61 complex: following membrane insertion of the first few transmembrane segments of proteins by the SEC61 complex, the MPT complex occludes the lateral gate of the SEC61 complex to promote insertion of subsequent transmembrane regions (PubMed:36261522). Within the MPT complex, the GEL subcomplex may mediate insertion of transmembrane regions into the membrane (PubMed:36261522)