Y+L amino acid transporter 1 (Monocyte amino acid permease 2) (MOP-2) (Solute carrier family 7 member 7) (y(+)L-type amino acid transporter 1) (Y+LAT1) (y+LAT-1)
1_MVDST 6_ EYEVA 11_ SQPEV 16_ ETSPL 21_ GDGAS 26_ PGPEQ 31_ VKLKK 36_ EISLL 41_ NGVCL 46_ IVGNM 51_ IGSGI 56_ FVSPK 61_ GVLIY 66_ SASFG 71_ LSLVI 76_ WAVGG 81_ LFSVF 86_ GALCY 91_ AELGT 96_ TIKKS 101_ GASYA 106_ YILEA 111_ FGGFL 116_ AFIRL 121_ WTSLL 126_ IIEPT 131_ SQAII 136_ AITFA 141_ NYMVQ 146_ PLFPS 151_ CFAPY 156_ AASRL 161_ LAAAC 166_ ICLLT 171_ FINCA 176_ YVKWG 181_ TLVQD 186_ IFTYA 191_ KVLAL 196_ IAVIV 201_ AGIVR 206_ LGQGA 211_ STHFE 216_ NSFEG 221_ SSFAV 226_ GDIAL 231_ ALYSA 236_ LFSYS 241_ GWDTL 246_ NYVTE 251_ EIKNP 256_ ERNLP 261_ LSIGI 266_ SMPIV 271_ TIIYI 276_ LTNVA 281_ YYTVL 286_ DMRDI 291_ LASDA 296_ VAVTF 301_ ADQIF 306_ GIFNW 311_ IIPLS 316_ VALSC 321_ FGGLN 326_ ASIVA 331_ ASRLF 336_ FVGSR 341_ EGHLP 346_ DAICM 351_ IHVER 356_ FTPVP 361_ SLLFN 366_ GIMAL 371_ IYLCV 376_ EDIFQ 381_ LINYY 386_ SFSYW 391_ FFVGL 396_ SIVGQ 401_ LYLRW 406_ KEPDR 411_ PRPLK 416_ LSVFF 421_ PIVFC 426_ LCTIF 431_ LVAVP 436_ LYSDT 441_ INSLI 446_ GIAIA 451_ LSGLP 456_ FYFLI 461_ IRVPE 466_ HKRPL 471_ YLRRI 476_ VGSAT 481_ RYLQV 486_ LCMSV 491_ AAEMD 496_ LEDGG 501_ EMPKQ 506_RDPKS
1: Heterodimer with SLC3A2, that functions as an antiporter which operates as an efflux route by exporting cationic amino acids from inside the cells in exchange with neutral amino acids plus sodium ions and may participate in nitric oxide synthesis via the transport of L-arginine (PubMed:10080182, PubMed:10655553, PubMed:14603368, PubMed:15756301, PubMed:15776427, PubMed:17329401, PubMed:9829974, PubMed:9878049). Also mediates arginine transport in non-polarized cells, such as monocytes, and is essential for the correct function of these cells (PubMed:15280038, PubMed:31705628). The transport mechanism is electroneutral and operates with a stoichiometry of 1:1 (By similarity). In vitro, Na(+) and Li(+), but also H(+), are cotransported with the neutral amino acids (By similarity)