Protein-arginine deiminase type-4 (EC 3.5.3.15) (HL-60 PAD) (Peptidylarginine deiminase IV) (Protein-arginine deiminase type IV)
1_MAQGT 6_ LIRVT 11_ PEQPT 16_ HAVCV 21_ LGTLT 26_ QLDIC 31_ SSAPE 36_ DCTSF 41_ SINAS 46_ PGVVV 51_ DIAHG 56_ PPAKK 61_ KSTGS 66_ STWPL 71_ DPGVE 76_ VTLTM 81_ KVASG 86_ STGDQ 91_ KVQIS 96_ YYGPK 101_ TPPVK 106_ ALLYL 111_ TGVEI 116_ SLCAD 121_ ITRTG 126_ KVKPT 131_ RAVKD 136_ QRTWT 141_ WGPCG 146_ QGAIL 151_ LVNCD 156_ RDNLE 161_ SSAMD 166_ CEDDE 171_ VLDSE 176_ DLQDM 181_ SLMTL 186_ STKTP 191_ KDFFT 196_ NHTLV 201_ LHVAR 206_ SEMDK 211_ VRVFQ 216_ ATRGK 221_ LSSKC 226_ SVVLG 231_ PKWPS 236_ HYLMV 241_ PGGKH 246_ NMDFY 251_ VEALA 256_ FPDTD 261_ FPGLI 266_ TLTIS 271_ LLDTS 276_ NLELP 281_ EAVVF 286_ QDSVV 291_ FRVAP 296_ WIMTP 301_ NTQPP 306_ QEVYA 311_ CSIFE 316_ NEDFL 321_ KSVTT 326_ LAMKA 331_ KCKLT 336_ ICPEE 341_ ENMDD 346_ QWMQD 351_ EMEIG 356_ YIQAP 361_ HKTLP 366_ VVFDS 371_ PRNRG 376_ LKEFP 381_ IKRVM 386_ GPDFG 391_ YVTRG 396_ PQTGG 401_ ISGLD 406_ SFGNL 411_ EVSPP 416_ VTVRG 421_ KEYPL 426_ GRILF 431_ GDSCY 436_ PSNDS 441_ RQMHQ 446_ ALQDF 451_ LSAQQ 456_ VQAPV 461_ KLYSD 466_ WLSVG 471_ HVDEF 476_ LSFVP 481_ APDRK 486_ GFRLL 491_ LASPR 496_ SCYKL 501_ FQEQQ 506_ NEGHG 511_ EALLF 516_ EGIKK 521_ KKQQK 526_ IKNIL 531_ SNKTL 536_ REHNS 541_ FVERC 546_ IDWNR 551_ ELLKR 556_ ELGLA 561_ ESDII 566_ DIPQL 571_ FKLKE 576_ FSKAE 581_ AFFPN 586_ MVNML 591_ VLGKH 596_ LGIPK 601_ PFGPV 606_ INGRC 611_ CLEEK 616_ VCSLL 621_ EPLGL 626_ QCTFI 631_ NDFFT 636_ YHIRH 641_ GEVHC 646_ GTNVR 651_ RKPFS 656_FKWWN
1: Catalyzes the citrullination/deimination of arginine residues of proteins such as histones, thereby playing a key role in histone code and regulation of stem cell maintenance (PubMed:15339660, PubMed:15345777, PubMed:16567635, PubMed:21245532). Citrullinates histone H1 at 'Arg-54' (to form H1R54ci), histone H3 at 'Arg-2', 'Arg-8', 'Arg-17' and/or 'Arg-26' (to form H3R2ci, H3R8ci, H3R17ci, H3R26ci, respectively) and histone H4 at 'Arg-3' (to form H4R3ci) (PubMed:15339660, PubMed:15345777, PubMed:16567635, PubMed:21245532). Acts as a key regulator of stem cell maintenance by mediating citrullination of histone H1: citrullination of 'Arg-54' of histone H1 (H1R54ci) results in H1 displacement from chromatin and global chromatin decondensation, thereby promoting pluripotency and stem cell maintenance (PubMed:15339660, PubMed:15345777, PubMed:16567635, PubMed:21245532). Promotes profound chromatin decondensation during the innate immune response to infection in neutrophils by mediating formation of H1R54ci (PubMed:18209087). Required for the formation of neutrophil extracellular traps (NETs); NETs are mainly composed of DNA fibers and are released by neutrophils to bind pathogens during inflammation (By similarity). Citrullination of histone H3 prevents their methylation by CARM1 and HRMT1L2/PRMT1 and represses transcription (PubMed:15345777). Citrullinates EP300/P300 at 'Arg-2142', which favors its interaction with NCOA2/GRIP1 (PubMed:15731352)